19:10 - 21:00
Poster Session 4 “Regulation of cytokine production”
Room: Ishikawa Ongakudō Interchange Hall
Poster Session
Tu-P4-1
IL-15/IL-15Rα complex controls the HSV-induced inflammation in a mouse model
Seonghyang Sohn1, 2, S M Shamsul Islam2, Bunsoon Choi1, Juyoung Choi2, Eun-So Lee3
1Department of Microbiology, Ajou University School of medicine, Suwon, Korea, Republic of (South), 2Department of Biomedical Science, Ajou University, Suwon, Korea, Republic of (South), 3Department of Dermatology, Ajou University, Suwon, Korea, Republic of (South)
Tu-P4-2
Spred-2 deficiency exacerbates lipopolysaccharide (LPS)/D-galactosamine (D-GalN) induced acute liver injury
Yang Xu, Teizo Yoshimura, Masayoshi Fujisawa, Toshiaki Ohara, Cuiming Sun, Akihiro Matsukawa
Department of Pathology and Experimental science, Okayama University, Okayama, Japan
Tu-P4-3
A Novel E3 ligase ZNRF1 regulates Toll-Like Receptor 4 Response
Ting Yu Lai1, Chih-Yuan Lee1, 2, I-Shing Yu3, Li-Chung Hsu1
1Institute of Molecular Medicine College of Medicine, National Taiwan University, Taipei, Taiwan, 2Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan, 3Laboratory Animal Center, College of Medicine, National Taiwan University, Taipei, Taiwan
Tu-P4-4
Transcytosis of Interleukin (IL-)11 and apical redirection of gp130 is mediated by IL-11a-receptor
Jürgen Scheller, Niloufar Monhasery
Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine University, 40225 Düsseldorf, Germany, Düsseldorf, Germany
Tu-P4-5
Dysfunction of Microglial STAT3 Alleviates Depressive Behavior via Neuron–Microglia Interactions
Sun-Ho Kwon1, Jeong-Kyu Han2, Moonseok Choi1, Yong-Jin Kwon1, Sung Joon Kim2, Eun Hee Yi1, Jae-Cheon Shin3, Ik-Hyun Cho4, Byung-Hak Kim1, Sang Jeong Kim2, Sang-Kyu Ye1
1Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 2Department of Physiology, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 3Pohang Center for Evaluation of Biomaterials, Pohang, Korea, Republic of (South), 4Department of Convergence Medical Science, College of Oriental Medicine, Kyung Hee University, Seoul, Korea, Republic of (South)
Tu-P4-6
Lung fibroblasts express miR-19a,19b,20a cluster to suppress transforming growth factor-β-associated fibroblast activation in murine pulmonary fibrosis
Kunihiko Soma1, 2, Shigeyuki Shichino1, 2, Shin-ichi Hashimoto1, 2, Hiroshi I Suzuki3, Satoshi Ueha1, 2, Kouji Matsushima1, 2
1Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Core Research for Evolutional Science and Technology (CREST), Advanced Research & Development Programs for Medical Innovation, Tokyo, Japan, 3David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, MA, United States
Tu-P4-7
The IFN response in the bat Pteropus alecto consists of canonical and non-canonical ISGs with distinct temporal expression patterns
Pamela C De La Cruz-Rivera1, Mohammed Kanchwala2, Hanquan Liang2, Ashwani Kumar2, Linfa Wang3, Chao Xing2, John W Schoggins1
1Department of Microbiology, UT Southwestern Medical Center, Dallas, United States, 2Department of Bioinformatics, UT Southwestern Medical Center, Dallas, United States, 3Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
Tu-P4-8
Role of TRAF7 in the Regulation of Type I IFN Antiviral Response
Rongtuan Lin, Yiliu Liu, Marie-Line Goulet
Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Canada
Tu-P4-9
Selected TLR7 agonist and IFN-α cytokine synergistically modulates gene expression of defense responses in microglia cells
Sarder Arifuzzaman1, Amitabh Das2, Kyoung Hwa Jung2, Young Gyu Chai1, 3
1Department of Bionanotechnology, Hanyang University, Ansan, 15588, Korea, Republic of (South), 2Institute of Natural Science & Technology, Hanyang University, Ansan, 15588, Korea, Republic of (South), 3Department of Molecular & Life Science, Hanyang University, Ansan, 15588, Korea, Republic of (South)
Tu-P4-10
Effect of nitric oxide-releasing derivative of indomethacin on Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages
Sung-Jo Kim1, In Soon Choi2, Eun-Young Choi2, So-Hui Choe2, Jin-Yi Hyeon2
1Department of Periodontology, School of Dentistry, Pusan National University, Gyeongsangnam-do, Korea, Republic of (South), 2Department of Biological Science, College of Medical and Life Sciences, Silla University, Busan, Korea, Republic of (South)
Tu-P4-11
Toll-like Receptor-10 is a novel regulator of immune responses in human plasmacytoid dendritic cells
Praik Deb1, 2, Nicholas James Hess4, Sukhwinder Singh1, 3, Richard Tapping4, 5, Patricia Fitzgerald-Bocarsly1, 2, 3
1Rutgers Biomedical and Health Sciences,, Newark, United States, 2Rutgers School of Graduate Studies, Newark, United States, 3Department of Pathology and Laboratory Medicine, New Jersey Medical School, Newark, United States, 4Dept. of Microbiology, University of Illinois, Urbana-Champaign, United States, 5College of Medicine, University of Illinois, Urbana-Champaign, United States
Tu-P4-12
Peritoneal mesothelial cell migration and myofibroblast differentiation are dependent on LPA- LPA1  
Norihiko Sakai, Taito Miyake, Koichi Sato, Akihiro Sagara, Shinji Kitajima, Tadashi Toyama, Yasunori Iwata, Miho Shimizu, Kengo Furuichi, Takashi Wada
Division of Nephrology, Kanazawa University, Kanazawa, Japan
Tu-P4-13
A novel terminal uridyltransferase regulates TLR4-driven IL-6 production via modulation of Regnase-1 mRNA stability
Chia-Ching Lin1, Yi-Ru Shen2, Chi-Chih Chang3, Li-Chung Hsu4
1Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, 2Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, 3Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, 4Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
Tu-P4-14
siRNA with a unique 5-nt motif potently suppresses IFI16-mediated innate immune response to intracellular DNA
Hongyan Sui1, Xiaojun Hu1, Brad T. Sherman1, H. Clifford Lane2, Tomozumi Imamichi1
1Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biochemical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, United States, 2National Institute of Allergy and Infectious Diseases, NIH, Bethesda, United States
Tu-P4-15
Identification of endogenous nucleic acid as a cause of inflammation and potential therapeutic target of inflammatory diseases
Hideo Negishi1, Nobuyasu Endo1, Yuki Nakajima1, Tatsuaki Nishiyama2, Junko Nishio1, Takeshi Doi2, Tadatsugu Taniguchi1
1Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan, 2Tokyo?New?Drug?Research?Laboratories Kowa Company, LTD., Tokyo, Japan
Tu-P4-16
The role of Blimp-1 in the differentiation and function of regulatory B cells
Ying-Hsiu Wang1, 2, Dong-Yen Tsai1, I-Ying Lin1, Kuo-I Lin1
1Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
Tu-P4-17
Advanced glycation end product-3 (AGE-3) inhibits osteoclast differentiation via down-regulation of RANK and up-regulation of IL-10
Kenichi Tanaka, Kaoru Yamagata, Satoshi Kubo, Shingo Nakayamada, Yosuke Okada, Yoshiya Tanaka
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Tu-P4-18
IL-9 regulates recall responses by memory B cells
Shogo Takatsuka1, 2, Hiroyuki Yamada2, Hiroshi Saruwatari2, Yoshitsugu Miyazaki1, Yuki Kinjo1, Daisuke Kitamura2
1National Institute of Infectious Diseases, Tokyo, Japan, 2Tokyo university of science, Chiba, Japan
Tu-P4-19
Study on the factors that may affect cytokine secretions in cultured kidney cells
Bai-Chia Liu, Bi-Fong Lin
Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan
Tu-P4-20
Characterization of the cytokines secretion by mouse mesangial cell line MES-13 and primary murine tubular epithelial cells
Yu-Ting Chen, Bi-Fong Lin
Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan
Tu-P4-21
Characterization of IFNL4 promoters from different species
Hao Zhou, Ewa Terczyńska-Dyla, Michelle Møhlenberg, Hans Henrik Gad, Rune Hartmann
Department of Molecular Biology and Genetics, Aarhus University, Aarhus. Denmark., Aarhus, Denmark
Tu-P4-22
Activation of glycogen synthase kinase-3β regulates cytokine production in TPA/ionomycin-activated human CD4(+)  T lymphocytes
Chia-Ling Chen1, Cheng-Chieh Tsai2, Po-Chun Tseng3, Chiou-Feng Lin3, 4
1Translational Research Center, Taipei Medical University, Taipei, Taiwan, 2Department of Nursing, Chung Hwa University of Medical Technology, Tainan, Taiwan, 3Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 4Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
Tu-P4-23
Cytokine macrophage migration inhibitory factor (MIF) facilitates cisplatin-induced acute kidney injury
Cheng-Chieh Tsai1, Chia-Ling Chen2, Po-Chun Tseng3, Chiou-Feng Lin3, 4
1Department of Nursing, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan, Taiwan, 2Translational Research Center, Taipei Medical University, Taipei, Taiwan, 3Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 4Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
Tu-P4-24
Ebolavirus Protein VP24 Interferes with Innate Immune Responses by Inhibiting Interferon gene expression
Felix B He1, Krister Melen1, 2, Sari Maljanen1, Rickard Lundberg1, Miao Jiang2, Pamela Österlund2, Laura Kakkola1, Ilkka Julkunen1
1Institute of Biomedicine/virology, University of Turku, Turku, Finland, 2Expert Microbiology Unit, National Institute of Health and Welfare, Helsinki, Finland
Tu-P4-25
The Regulation of Type I IFN Induction by The Serine Protease Hepsin
Fu Hsin1, Shuwha Lin2, Helene Liu1
1Department of Biochemistry and Molecular Biology, National Taiwan University, Taipei, Taiwan, 2Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, Taipei, Taiwan
Tu-P4-26
E74-like factor 3 (ELF3) is synergistically regulated by IL-17A and TNF and controls the production of inflammatory cytokines and matrix metalloproteinases in synovial fibroblasts
Vesa-Petteri Kouri1, Juri Olkkonen1, Nitai Peled1, Mari Ainola1, Kari Eklund1, 2, 3, Dan Nordstrom1, 2, Jami Mandelin1
1University of Helsinki, Helsinki, Finland, 2Helsinki University Hospital, Helsinki, Finland, 3ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland
Tu-P4-27
Cell-surface levels of IL-6R and gp130 are differentially controlled by endocytosis and recycling in dependence upon IL-6
Charlotte Margaret Joan Flynn, Tina Daunke, Birte Kespohl, Stefan Rose-John, Christoph Garbers, Samadhi Aparicio-Siegmund
Institute of Biochemistry Kiel University, Kiel, Germany
Tu-P4-28
Involvement of poly-rC binding proteins in posttranscriptional regulation of Sortilin, the cytokine trafficking mediator
Toshiki Yabe-Wada1, 2, Shintaro Matsuba1, Kazuya Takeda1, Akira Nakamura1, Caroline C Philpott2, Nobuyuki Onai1
1Kanazawa Medical University, Uchinada, Japan, 2National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, United States
Tu-P4-29
A lipoprotein LprG of Mycobacterium tuberculosis generates IL-10-producing tolerogenic plasmacytoid dendritic cells during differentiation
Hongmin Kim, Kee Woong Kwon, Woo Sik Kim, Sung Jae Shin
Department of Microbiology, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, South Korea, Seoul, Korea, Republic of (South)
Tu-P4-30
The quantity of initial FcRγ signaling determines cytokine profile in dendritic cells
Miyuki Watanabe1, 2, Sho Yamasaki1, 2
1Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan, 2Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
Tu-P4-31
Hypoxia up-regulates IL-4/IL-13-induced arginase-1 expression in mouse macrophages
Miki Hiroi
Division of Microbiology and Immunology Departments of Oral Biology and Tissue Engineering Meikai University School of Dentistry, Sakado, Japan
Tu-P4-32
A link between IRF5 genetic variants and onset of systemic lupus erythematosus
Dan Li, Betsy Barnes, Bharati Matta, Su Song
Northwell Health, Manhasset, United States
Tu-P4-33
Umbilical cord-derived mesenchymal stromal cells attenuate H5N1-associated acute lung injury in vitro
Hayley Loy1, Denise Iok Teng Kuok1, Kenrie Pui Yan Hui1, John Malcolm Nicholls2, Joseph Sriyal Malik Peiris1, Michael Chi Wai Chan1
1Centre of Influenza Research and School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, 2Department of Pathology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
Tu-P4-34
The novel ubiquitin ligase complex, NQO1-PDLIM2 inhibits TLR-dependent production of selective cytokines by degrading IκB-ζ
Akihiro Kimura, Masayuki Kitajima, Harumi Suzuki
Dept. of Immunology and Pathology, Research Institute National Center for Global Health and Medicine, Ichikawa-shi, Japan
Tu-P4-35
Functional analysis of 2 amino acids deleted transcription factor C/EBP epsilon found in neutrophil-specific granule deficiency
Tadayuki Akagi1, Taizo Wada2, Masahiro Muraoka2, Tomoko Toma2, Kenzo Kaji3, Kazunaga Agematsu4, H. Phillip Koeffler5, 6, Akihiro Yachie2, Takashi Yokota1
1Department of Stem Cell Biology, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 2Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 3Department of Dermatology, Komatsu Municipal Hospital, Komatsu, Japan, 4Department of Infection and Host Defense, Shinshu University Graduate School of Medicine, Matsumoto, Japan, 5Division of Hematology and Oncology, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, United States, 6Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
Tu-P4-36
Loss of function of Baf53a (a subunit of chromatin remodeling complex) results in cell death and Baf53b, as well as Baf53a, rescue the phenotype in mouse ES cells
Bo Zhu, Ueda Ueda, Xiaohong Song, Tadayuki Akagi, Takashi Yokota
Department of Stem Cell Biology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan, Kanazawa, Japan
Tu-P4-37
The early synthesized CDK5-p35 complexes suppress interleukin-10 production through inhibition of binding partners that regulate MAPK activation in LPS-stimulated macrophages
Daun Jung, Yirang Na, Seung Hyeok Seok
Macrophage Laboratory, Department of Microbiology and Immunology, and Institute of Endemic Disease, Seoul National University College of Medicine, 103 Daehak-ro, Chongno-Gu, Korea, Republic of (South)