Introduction: Migraine and mild traumatic brain injury (mTBI) are common in children, adolescents, and adults. Regarding memory function, limited data is currently available for both migraine and mTBI compared to healthy controls, and especially long-term memory has not been investigated yet. In migraine and mTBI evidence points at activity changes in networks, which play a role in memory function.
Methods: Memory function is investigated using a computer-based tool with an iterative, adaptive paired-associate test presenting verbal and non-verbal visual items. Memory consolidation strength is calculated based on the rate of the forgetting (RoF) of each particular item. Differences in RoF are investigated between patients with migraine or mTBI and healthy controls in cohorts of adult migraine, pediatric migraine, and pediatric mTBI, respectively. In addition, within-subjects comparison of RoF in adult migraine patients is done for 3 time points across 4 months.
Results: Results of preliminary analyses will be available at the time of the conference.
Conclusion: The findings of these studies may help to evaluate whether RoF can serve as a lokw-cost sensitive behavioral marker during trajectory of migraine and mTBI. A low invasive, highly precise adaptive computerized, point of care tool to monitor cognition will be of great value both in day-to-day care and scientific research. Despite the importance of neuropsychological testing in clinical settings, the currently available tools afford both time and trained professionals performing the tests. Therefore, a novel tool based on RoF could help to offer cognitive testing with low threshold.