For many young residents, living in the city of Abidjan is a matter of not only grasping how to collaborate and live alongside others, but also how to cohabitate with spiritual forces that impinge upon the im/material realm of their lives. Confronted with forms of material and spiritual uncertainties related to such issues as chronic underemployment or afflictions resulting from the action of malevolent spiritual forces, numerous young residents turn to Animist, Christian and Muslim specialists of esoteric knowledge to strive against or to influence the dynamics of the spiritual realm. While there is a widely shared perception among young people that Abidjan is home to numerous charlatans, tricksters or unreliable specialists of esoteric knowledge, they privilege the engagement in forms of spiritual healing based in rural areas of the national territory. Based on ethnographic fieldwork conducted during the course of 23 months in Côte d'Ivoire between 2016 to 2018, this communication analyses these forms of immaterial connections in order to understand the place and role of the sacred in urban life. For numerous young men, in particular, the clandestine and individual consultation of animist healers in secluded and remote areas is often a matter of quickly getting an efficient, occult medicine geared to curb social and economic blockages and subsequently access the socio-spiritual resources necessary to achieve social adulthood in a time of chronic underemployment. For many other young urban dwellers facing various kind of afflictions, the engagement in long-lasting Islamic or Christian activities of self-transformation in large-scale healing centers also situated outside of the metropolis is seen as an effective way to strengthen their faith and prevent new attacks from malicious spiritual forces like jinn, demons or witchcraft. What is shown through these particular ways of connecting with divergent forms of spiritual healing is not only the entanglement of the spiritual and material dimensions but also the sprawling connections between city dwellers and various rural spaces that provide them with a range of spiritual resources to face their afflictions. Among young urbanites, extensive circulation of narratives that address the potentialities of those trans-local immaterial connections also lead to constant new desires and experiences of mobility, as well as unexpected re-imaginations of urban life through the incorporation of spiritual practices and ethical transformations that emanate principally outside the city.