The main objective of this paper is to explore the dynamics of interfaith marriages by engaging how secularism, individual subjectivity and pragmatism have mediated and partly blunted the divisive tendencies of Muslims and Christians in Ghana. The objective of the paper is to reflect on how interfaith marriages and other forms of conjugal relationships between Muslims and Christians have become existential social realities in Ghana. Both Islam and Christianity are missionary-oriented religions and have dogmas that are mutually exclusive. The two religions also have eschatology teachings that aspire for future global dominance. In addition to that, the two religions also have social structure that discourages interfaith marriages. Thus, from the point of view of theology and sociological structure of these religions, tension and conflicts between religious adherents are predicable. The quest on the part of each of these religions to keep their pristine teachings has been expressed in their prohibition of interfaith marriages. Both Christians and Muslims invoke history and religious texts to discourage interfaith marriages. Nevertheless, interfaith marriages (including marriage between a Muslim woman and a non-Muslim man) between these two religions remain existential social fact in Zongo communities. The paper would historicise interfaith marriages between these two faiths, at least in the first century of Islam. And since Islam was in Ghana (then Gold Coast), about a century, before Christianity, the paper would discuss how the Muslims related with non-Muslims in pre-colonial Ghana. Attention would also be paid to how tcolonial policies shaped Muslim-Christian relationship in Gold Coast. In postcolonial Ghana, the paper would examine how the evolution of Zongo communities from Islamic communities to religiously pluralistic communities has shaped Muslim-Christian relationship. The paper would also examine how individuals negotiate and renegotiate with the conventional teachings of their respective religions to re-theologise and re-conceptualise interfaith marriages and other forms of conjugal relationships. As part of the dynamics of interfaith marriages, the paper would analyse the socio-legal consequences of interfaith marriages, and how individuals are able to explore available opportunities, including the secular constitution and other legal instruments, to overcome the challenges posed by interfaith marriages. The paper would further provide a section on how individuals crisscross religious boundaries to establish interfaith marriages. Finally, the paper would discuss the future of interfaith marriages, by pointing out how religious reformers in both Christianity and Islam are reengaging interfaith marriages in Ghana. Broadly, the paper would reflects how globalisation, cosmopolitanism, neoliberalism, and western education have cohered to mediate and shape Muslim-Christian relationships and in the process sustained interfaith marriages and other forms of conjugal relationships in Ghana. As an ethnographic study, the paper depends on data gathered from three Zongo communities – Maamobi, Nima, and Madina – in Accra between May and July 2017.