The word ghetto conjures a terrible image and reminds the world of the marginalisation of the Jewish people in Eastern Europe. In the case of Zongo communities (‘strangers’ quarters) in Accra, the ghetto serves as a social space for the expression of marijuana culture, by people who suffer marginalisation because of their consumption of marijuana. In this paper, my focus is to analyse the sociogenic and cultogenic nature of marijuana culture, and how that provides a sub-culture in the social space of ghetto in Maamobi community. Departing from the criminalisation of the consumption of the substance, which obliterates and obstructs a balanced assessment of marijuana culture, my paper engages with marijuana culture as a form of popular and youth culture that engages with so-called mainstream cultures at different levels. A sociological understanding of the marijuana culture, as opposed to the stigmatisation and straitjacketing of marijuana consumers, would shed light on the vexatious debate over the substance in Ghana. More specifically a sociological approach to engaging marijuana culture would help us solve the paradox of why marijuana consumption is illegal in Ghana, and yet Ghanaian consumers of the substance rank first in Africa and third in the world. This is to the extent that the consumption of the substance transcends religious, political, economic, and social boundaries. This makes the ghetto a social space for the crafting of social structure that shapes anthropocentric relationships among consumers. The sociological structure of the ghetto creates a fictive family that operates at a level of ‘us’ and ‘them’ in the engagement between consumers and non-consumers. The paper would contribute to how individuals appropriate ghetto as a social space to overcome marginalisation and stereotyping in Ghana. Consequently, the paper would look at how the ghetto as a social space shapes the rules, political structure, socialization and initiation of neophytes into the marijuana culture, and the linguistic ingenuity of marijuana consumers. The presentation depends on data gathered in 2009-2010.