A longstanding question in the field of spatial compatibility effects recruits to the idea whether multiple spatial compatibility effects are simultaneously possible. These different compatibility effects are indicative of different reference frames used in spatial cognition. Previous studies postulated that simultaneous Simon effects (one particular form of spatial compatibility effects) are in principle formed but only one Simon effect was effectively found, depending on the exact experimental manipulation (Umiltà & Liotti, 1987). Other studies supported this claim further by showing multiple Simon effects when participants were given informative cues or the general spatial layout beforehand (Lamberts et al, 1992; Roswarski & Proctor, 1996). These findings are – to some extent – at odds with recent findings reporting simultaneous Simon effects without any additional information provided (Baess et al, 2022). In the present study, both different version of the Simon task with multiple reference frames (i.e. the one used in Roswarski & Proctor, 1996 and Baess et al, 2022, respectively) were collected for the same group of participants. The talk will report the results of this direct comparison of the two versions of the Simon task. Further, the role of experimental manipulation such as informative precues and spatial arrangements in general are discussed.