Stable spatial arrangement of items can efficiently guide attentional selection and facilitate visual search over time, a phenomenon known as contextual cuing. On the other hand, updating of already formed long-term context memories in the relocation is rigid. In the current work, we explored whether global context regularities can guide and mis-guide early attentional selection in the absence of individual item identities. We used lateralized event-related electroencephalogram potentials and presented a group of participants (N = 16) with repeated and non-repeated displays that were preceded by a spatial mask for 500 ms. The mask contained placeholders of search items that didn’t reveal the identity of the search items. We found a reliable contextual cuing during the initial learning phase, which was associated with an early N1pc ERP component: negativity that peaks ~150 ms after stimulus onset. Contextual cuing was effectively abolished in the relocation phase, and the N1pc was reversed in polarity, which is indicative of persistent misguidance of attention to the original target location. Repeated layouts proactively interfere with contextual relearning after target relocation, even in the absence of stimulus identities.