08:30 - 10:00
Wed-A7-Talk VI-
Wed-Talk VI-
Room: A7
Chair/s:
Angelika Dierolf
The aging population is disproportionally affected by pain and its consequences. Aging is known to affect neurobiological aspects of pain perception and has been associated with a deterioration of descending pain inhibitory mechanisms. However, little is known about whether cognitive pain modulatory mechanisms are preserved in the older age. Here, we present a series of studies on cognitive and situational factors influencing pain processing and the efficacy of cognitive pain modulation on the behavioral and (neuro)physiological level, focusing on underlying neural mechanisms to gain insight in the changes of the aging brain associated with pain processing and pain modulation.
Ana María González Roldán will start presenting data from several electrophysiological studies examining how aging and chronic pain may mutually contribute to enhanced pain perception. Further expanding on chronic pain, Joukje Oosterman will present a study on the underlying neural mechanism of loss of control over pain in aging, a predictor for future chronic pain. She will focus on age-related changes in function and EEG-connectivity in brain circuits involved in pain processing in relation to top-down cognitive modulation of pain control. Turning to distraction from pain as a top-down inhibitory process, Marian van der Meulen will discuss the relationship between functional connectivity during resting state and the distraction effect size in younger and older healthy adults. The role of executive functions and age-related cognitive decline in distraction from pain is addressed by Angelika Dierolf, presenting results of an EEG study. Finally, Sven Philipsen will discuss the impact of acute stress on the efficacy of distraction from pain in young and older adults.
Age differences in perceived locus of control over pain
Wed-A7-Talk VI-02
Presented by: Joukje Oosterman
Joukje Oosterman 1, Simon Kern 2, Inti Brazil 1
1 Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands, 2 Central Institute of Mental Health, Mannheim, Germany
Aging is characterized by a decline in the top-down modulation of pain. These top-down modulatory processes play a major role in daily life situations where painful events occur unexpectedly and beyond a person’s control. To date, however, it is unclear how a perceived lack of control influences the perception of pain and the underlying modulatory brain regions in aging.

In the present study, we manipulated the perceived locus of control over a low and a high pain stimulus in a group of younger (n=16, age=23.1) and older (n=20, age=63.6) participants. Each participant's personalized level of low and high pain experience was determined using electric shocks. Next, participants were informed that they would receive either their personalized low or high painful stimulus (high control), or a low or high level of stimulation generated by the computer (low control). Unknown to them, the computer-generated intensities were the same as the personalized low and high levels. We recorded participants’ experienced level of control over the self versus the computer-generated shocks, and after each shock participants rated their level of pain. Electroencephalography (EEG) was also recorded. Preliminary analyses indicate that, in both age groups, participants reported higher levels of control over their personalized compared to the computer-generated electric shocks. Moreover, in both age groups a similar effect was found where subjective pain ratings were lower following computer-generated pain. Further analysis will focus on the electrophysiological correlates of the anticipatory and shock phase, comparing them between self and computer-controlled trials for both age groups.
Keywords: pain control, aging, expectation, pain experience, top-down modulation, EEG