The effect of a sweet-tasting pentose [L-arabinose] on glycaemic and insulinaemic responses after sugar consumption in a prediabetic population
Wed-P2-065
Presented by: Leoné Pretorius
Background: L-arabinose is a sweet-tasting pentose reported to inhibit sucrase activity in the brush border of the small intestine. L-arabinose could serve as a functional ingredient to lower glycaemic responses after the consumption of sugar in people with prediabetic symptoms.
Objective: To assess the effects of L-arabinose supplementation on glycaemic and insulinaemic responses in a prediabetic population.
Methods: Eighteen adults (4 female/14 male; aged 73±4 years; BMI: 27.5±2.4 kg/m2) with prediabetic symptoms participated in a double-blind randomised cross-over trial with two treatments. In the intervention treatment, participants received L-arabinose (5g) added to a 50g sucrose drink. In the control treatment, participants received a sucrose-only drink. Circulating glucose and insulin concentrations were determined at fixed time points: before, 15, 30, 45, 60, 90, 120, and 180 min after consumption.
Results: The addition of L-arabinose to the control drink significantly lowered and delayed the peak glucose concentration (p<0.001): 8.3±1.1 mmol/l after 53±21 min compared to the control drink (9.5±1.5 mmol/l after 43±12 min). Insulinaemic responses were also significantly lower and delayed (p<0.01): 57.2±41 mmol/l and 40±23.8 mmol/l after 46±17 min and 78±30 min for the control drink compared to the addition of L-arabinose, respectively. The incremental area under the curve (iAUC) of the total glucose response tended to be lower after the addition of L-arabinose (p=0.09), whereas the iAUC for the insulin response was significantly lowered by 25%.
Conclusion: The consumption of L-arabinose together with sucrose results in a lower and delayed postprandial glycaemic and insulinaemic response in a prediabetic population.
Funding: This study was completed as part of the Pulp2Value project under the European Union (grant agreement No. 669105). This analysis was undertaken as part of a PhD studentship funded by Bournemouth University and Wageningen University and Research.
Objective: To assess the effects of L-arabinose supplementation on glycaemic and insulinaemic responses in a prediabetic population.
Methods: Eighteen adults (4 female/14 male; aged 73±4 years; BMI: 27.5±2.4 kg/m2) with prediabetic symptoms participated in a double-blind randomised cross-over trial with two treatments. In the intervention treatment, participants received L-arabinose (5g) added to a 50g sucrose drink. In the control treatment, participants received a sucrose-only drink. Circulating glucose and insulin concentrations were determined at fixed time points: before, 15, 30, 45, 60, 90, 120, and 180 min after consumption.
Results: The addition of L-arabinose to the control drink significantly lowered and delayed the peak glucose concentration (p<0.001): 8.3±1.1 mmol/l after 53±21 min compared to the control drink (9.5±1.5 mmol/l after 43±12 min). Insulinaemic responses were also significantly lower and delayed (p<0.01): 57.2±41 mmol/l and 40±23.8 mmol/l after 46±17 min and 78±30 min for the control drink compared to the addition of L-arabinose, respectively. The incremental area under the curve (iAUC) of the total glucose response tended to be lower after the addition of L-arabinose (p=0.09), whereas the iAUC for the insulin response was significantly lowered by 25%.
Conclusion: The consumption of L-arabinose together with sucrose results in a lower and delayed postprandial glycaemic and insulinaemic response in a prediabetic population.
Funding: This study was completed as part of the Pulp2Value project under the European Union (grant agreement No. 669105). This analysis was undertaken as part of a PhD studentship funded by Bournemouth University and Wageningen University and Research.