In the Bruce effect, pregnant mice miscarry following exposure to bodily odors emitted from a male stranger. Lesions to the female accessory olfactory system negate this effect. Bruce-like effects have been implicated in other mammals, and in our previous study (Rozenkrantz et al, eLife, 2020), we found that women who experienced uRPL displayed altered perceptual and brain responses to men’s body-odor (BO), suggesting a possible link between uRPL and the olfactory system. In our current study, we sought to examine the contribution from men by asking whether uRPL-men and control-men emit different BO. We collected BOs from the spouses of the women who participated in our previous study, using T-shirts worn for two consecutive nights. Twenty-one women with uRPL and 24 control women sniffed and rated 34 BO jars (17 uRPL-men, not their spouse) on a visual analogue scale. We found that uRPL-men’s BO was rated as more pleasant, sexually attractive and fertile than control men’s (rmANOVAs for each parameter but intensity revealed a significant effect of men BO type (all F(1,43)>14.24, all p<0.001), no women-group effect or interaction). Fifty-one nulliparous women who are not related to the study performed the same task, and the results were replicated (pleasantness, sexual attraction and fertility: all t(50)>2.88, p<0.006, intensity: t(50)=0.87, p=0.38). We then used a PEN3 electronic nose (eNose, Airsense) to sample 37 male BOs (18 uRPL). Using the data from the 10 sensor 80-second time series, a Linear SVM classifier successfully classified the odors to uRPL or control-men at 69.9% accuracy in a five-fold cross-validation test (p<0.001 estimated by repeating the process 1000 times and shuffling the labels). These initial results suggest that uRPL and control-men’s BO have different chemical composition. This implies a possible contribution of men to the effect we found in Rozenkrantz et al, and combined, further strengthen a link between uRPL and the olfactory system.