Olfaction plays some major functional roles in fish. Lepidocephalichthys guntea [Hamilton, 1822] is a small indigenous fish of South-East Asia [IUCN Red List category: Least Concern, ver. 3.1]. Lamina propria is composed of different types of cells viz., endothelial cell, macrophage, fibroblast cell, schwan cell, mast cell and secretory granulocytes. The evidence of axon bundles is frequently characterized within the lamina propria region of fish using 2.5% glutaraldehyde as primary fixative and 1% solution of osmium tetroxide as secondary fixative in 0.1M phosphate buffer, pH 7.2-7.4 at 40C and viewed under transmission electron microscope [AIIMS, New Delhi]. Fibroblasts are the pluripotent connective tissue cells of olfactory neuroepithelium in fish. From our observation at the time of neurogenesis, the fibroblast cell shows functional morphs. These cells are morphologically spindle in shape, with an elongated nucleus and a thin rim of cytoplasm. In fish, they may be regarded as the residential fibroblast cells. At the time of neurogenesis, the fibroblast cell shows a distinctive character, having prominent golgi apparatus, rough endoplasmic reticulum, active mitochondria, numerous secretory vesicles and evidence of pro collagen substances. Probably the formation of procollagen within the lamina propria region is the indication for the synthesis of extracellular substances that may trigger the functional integrity of the respective tissue concerned.