Understanding how our spatial memory and navigation systems depend on sensory impressions is a key issue in psychology. These cognitive abilities are strongly associated with olfaction. It has been proposed that olfaction co-evolved with navigation, and spatial memory for animals to find food sources. In contrast, the higher senses (sight and hearing) exhibit greater neuroanatomical separation between perceptual and cognitive processes. Such differences in structural organization between the senses could cause the spatial memory to prioritize olfaction, leading to “overwriting” of sound-based representations with smell-based ones. In this study, we used Virtual Reality (VR) technology with a custom-made hand-held olfactometer, to explore sensory interference effects in our spatial memory and navigation systems. Participants memorized locations of smell (olfactory condition) and sound objects (auditory condition) within two visually identical virtual environments. Participants first completed memory encoding and recall tasks in both conditions separately, with the initial condition randomized across participants. This was followed by a global recall of locations of smell and sound objects in a random order, and a one-week delayed global recall. Performance was measured as a distance error between original and recalled locations. Results showed stronger presence of retroactive interference of smells on sounds, rather than vice-versa. Specifically, for participants who first encoded locations in the auditory condition, performance during global recall declined for sounds, but not for smells, suggesting that the memory representation of smells interfered with that of sounds. These results support the idea of olfactory dominance in our spatial memory, aligning with recent research in non-spatial working memory tasks. Funded by the Consolidator grant from the Swedish Research Council for Jonas Olofsson "What can the sense of smell teach us about higher brain functions?"