15:45 - 17:15
Tue-P1
Room: Waalsprong 4
Neural differences in odor encoding and odor recognition memory in Parkinson’s disease with and without cognitive impairment.
Tue-P1-010
Presented by: Charalampos Georgiopoulos
Tom Eek 1, 2, Fredrik Lundin 1, Nil Dizdar 1, Maria Larsson 3Charalampos Georgiopoulos 2, 4
1 Department of Neurology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden, 2 Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden, 3 Gösta Ekman Laboratories, Department of Psychology, Stockholm University, Stockholm, Sweden, 4 Diagnostic Radiology, Department of Clinical Sciences, Medical Faculty, Lund University, Lund, Sweden
Objectives: To investigate the variations in brain activity among healthy individuals, Parkinson's Disease patients without(PD) and with mild cognitive impairment (PD-MCI) during an odor encoding (OE) and odor recognition memory (ORM) fMRI experiment, building upon our previous finding that correct odor recognition is associated with neural suppression in the insula and limbic system.
Methods: Thirty-one healthy controls and 31 PD patients (20 PD and 11 PD-MCI) were examined with fMRI across OE and ORM. Independent Component Analysis was employed to analyze the data, and group differences were tested using ANOVA.
Results: One OE component (3.4% of explained variance) consisted of the anterior piriform cortex, basal ganglia, and anterior insula. PD-MCI patients exhibited significantly lower recruitment of this network compared to both healthy controls (p<0.001) and PD patients (p=0.003), with no significant difference between healthy controls and PD patients. One ORM component (3.8% of explained variance) included the amygdala, posterior piriform cortex, entorhinal cortex, hippocampus, thalamus, and anterior insula bilaterally. Healthy controls exhibited significantly higher recruitment of this network compared to PD (p=0.018) and PD-MCI (p<0.001) patients, while no significant difference was observed between PD and PD-MCI patients. Hit responses during ORM differentiated PD patients with and without MCI from healthy controls (p=0.042 and p<0.001, respectively). False alarms did not differ significantly between the groups. There was no significant difference in age between PD and controls or PD and PD-MCI.
Conclusions: These preliminary results illustrate that PD-MCI patients demonstrate reduced engagement of areas related to olfaction during OE. ORM successfully differentiated between healthy controls and patients, but not between the two PD subgroups.
Funding: The study was financed by Swedish governmental funding of clinical research (ALF).