The symposium will highlight novel findings in the field of chemosensing in extra nasal tissues with relevance for health and disease. In particular, the symposium will focus on the specific roles of olfactory receptors and bitter receptors and their underlying mechanisms in the gastro intestinal tract, the immune system and the vascular system, in relation to metabolic health, inflammation and blood pressure. The field of chemosensing in extra nasal-oral tissues is a new and exciting area of science of high importance to (patho)physiology.