Functional connectivity patterns in patients with parosmia
Fri-P2-083
Presented by: Divesh Thaploo
Introduction:
Imagine smelling a pleasant odor like peach as completely disgusting and unpleasant, as faeces. Very less is known about this condition called “parosmia” which has a direct impact on diet, mental health and quality of life. Among other suggestions, aberrant recovery of olfactory sensory neurons has been suggested as possible explanation for this phenomenon. We aim to study parosmia associated with anosmia and hyposmia using functional imaging and try to explain this shift from pleasant to unpleasant.
Methods:
In total, 152 functional anosmic and hyposmic patients (with and without parosmia) underwent resting state functional magnetic resonance imaging (rs-fMRI) using a 3T scanner (Siemens, Germany). Patients were asked to fixate on a cross during the entire duration of scanning. In total 240 volumes were acquired with a TR = 2060ms. We also acquired a high resolution T1 structural image. Currently, we analysed 6 parosmic patients with functional anosmia (47 ± 13 years, 3 women) and 9 parosmic patients with hyposmia (44 ± 20 years, 6 women) using functional connectivity based on the following seeds: bilateral piriform cortex and bilateral orbitofrontal cortex. Seed based functional connectivity tells which other brain area have similar activity patterns as the seed. All analysis was carried out using FSLv6.0.2 and results are reported at p<0.05 and cluster size>3.1.
Results:
The left piriform cortex was functionally connected with bilateral insula in the group with functional anosmia while the left orbitofrontal cortex was more connected with right dorsal anterior cingulate cortex. In the hyposmic group the left piriform cortex was functionally connected with the bilateral putamen while the left orbitofrontal cortex was more connected with the left prefrontal cortex and left angular gyrus.
Conclusions: Patients with parosmia seem to exhibit different patterns of connectivity in relation o the degree of olfactory loss.
No funding was available.
Imagine smelling a pleasant odor like peach as completely disgusting and unpleasant, as faeces. Very less is known about this condition called “parosmia” which has a direct impact on diet, mental health and quality of life. Among other suggestions, aberrant recovery of olfactory sensory neurons has been suggested as possible explanation for this phenomenon. We aim to study parosmia associated with anosmia and hyposmia using functional imaging and try to explain this shift from pleasant to unpleasant.
Methods:
In total, 152 functional anosmic and hyposmic patients (with and without parosmia) underwent resting state functional magnetic resonance imaging (rs-fMRI) using a 3T scanner (Siemens, Germany). Patients were asked to fixate on a cross during the entire duration of scanning. In total 240 volumes were acquired with a TR = 2060ms. We also acquired a high resolution T1 structural image. Currently, we analysed 6 parosmic patients with functional anosmia (47 ± 13 years, 3 women) and 9 parosmic patients with hyposmia (44 ± 20 years, 6 women) using functional connectivity based on the following seeds: bilateral piriform cortex and bilateral orbitofrontal cortex. Seed based functional connectivity tells which other brain area have similar activity patterns as the seed. All analysis was carried out using FSLv6.0.2 and results are reported at p<0.05 and cluster size>3.1.
Results:
The left piriform cortex was functionally connected with bilateral insula in the group with functional anosmia while the left orbitofrontal cortex was more connected with right dorsal anterior cingulate cortex. In the hyposmic group the left piriform cortex was functionally connected with the bilateral putamen while the left orbitofrontal cortex was more connected with the left prefrontal cortex and left angular gyrus.
Conclusions: Patients with parosmia seem to exhibit different patterns of connectivity in relation o the degree of olfactory loss.
No funding was available.