19:10 - 21:00
Poster Session 14 “Cytokines in cancer development and antitumor immune therapy”
Room: Ishikawa Ongakudō Interchange Hall
Poster Session
Tu-P14-1
Identification of driver proteins for accelerating immune system recovery
Tania Dubovik, Elina Starosvetsky, Shai Shen-Orr, Mayan Levy, Karen Regev Berman
Rappaport Institute of Medical Research, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Tu-P14-2
Context-dependent diverse roles of CCR5-mediated signals in chronic myeloid leukemia (CML) pathogenesis
Tomohisa Baba, Naofumi Mukaida, Yamato Tanabe
Division of Molecular Bioreguration, Cancer Research Institute, Kanazawa University, Kanazawa-shi, Japan
Tu-P14-3
Lentivirus mediated RNA interference of EMMPRIN (CD147) gene inhibits the proliferation, matrigel invasion and tumor formation of breast cancer cells
Xiaoqin Yang, Jing Yang
Department of Breast Surgery, West China Hospital, Sichuan University. China, Chengdu, China
Tu-P14-4
Interleukin-2 inhibits the differentiation of follicular cytotoxic CD8+ T cells during chronic viral infection
Yaping Chen1, 2, Di Yu3, 4, Yew Ann Leong1, Yunbo Wei4, Hongsheng Ong3, Hao Wang3
1School of Biomedical Sciences, Monash University, Melbourne, Australia, 2Melbourne Centre for Nanofabrication, Melbourne, Australia, 3John Curtin School of Medical Research, The Australian National University, Canberra, Australia, 4Shandong Analysis and Test Center, Shandong Academy of science, Shandong, China
Tu-P14-5
Characterization of a novel subset of tissue-resident NKp46pos Vd1 intestinal intraepithelial lymphocytes playing a key role in gut immune homeostasis and in the physiopathology of colon-cancer.
Domenico Mavilio1, 6, Joanna Mikulak1, 2, Ferdinando Oriolo1, Alessandra Roberto1, Elena Bruni1, Paolo Tentorio1, Federico Colombo3, Michele Carvello4, Antonino Spinelli4, Bruno Silva-Santos5
1Unit of Clinical and Experimental Immunology, Humanitas Clinical and Research Center,, Rozzano, Milan, Italy, 2Institute of Genetic and Biomedical Research (IRGB), CNR, Milan, Italy, Italy, 33Flow Cytometry and Cell Sorting Unit, Humanitas Clinical and Research Center, Rozzano, Milan, Italy, 4Colon and Rectal Surgery Unit, Humanitas Clinical and Research Center, Rozzano Milan, Italy, 5Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal, 6Department of Medical Biotechnologies and Translational Medicine (BioMeTra), University of Milan, Milan, Italy
Tu-P14-6
NOD1 triggers epithelial intrinsic processing of pro-interleukin-18 to protect the gastric mucosa from pre-cancerous changes induced by chronic Helicobacter pylori infection
Le Son Tran1, Hassan Chaudhry1, Kimberley D'costa1, Amanda De Paoli1, Julia Como1, Jennifer Dowling1, Jonathan Ferrand1, Ashley Mansell1, Ben A. Croker2, Ueli Nachbur2, Seth L. Masters3, Richard L. Ferrero1
1Hudson Institute of Medical Research, Monash University, Melbourne, Australia, 2Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 3The Walter and Eliza Hall Institute, Melbourne, Australia
Tu-P14-7
MicroRNAs as modulators of cytokine responses
Iris Behrmann1, Florence Servais1, Mélanie Kirchmeyer1, Petr Nazarov2, Matthias Glanemann3, Frank Lammert4, Claude Haan1, Stephanie Kreis1
1University of Luxembourg, Life Sciences Research Unit, Belvaux, Luxembourg, 2Genomics Research Laboratory, Luxembourg Institute of Health, Luxembourg, Luxembourg, 3Department of Surgery, Saarland University Medical Center, Homburg, Germany, 4Department of Medicine II, Saarland University Medical Center, Homburg, Germany
Tu-P14-8
Adult T cell leukemia (ATL) cell-produced brain derived neurotrophic factor (BDNF) induces regulatory T cells and attenuates immune responses.
Yasuhiro Yoshida1, Yuan Song1, Duo Wang1, Tsukasa Nakanishi1, 2, Junichi Tsukada2
1Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 2Department of Hematology, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan
Tu-P14-9
Downregulation of type I interferon receptor within tumors establishes a localized immune privileged niche and attenuates anti-cancer immune therapies
Serge Y. Fuchs
University of Pennsylvania, Philadelphia, United States
Tu-P14-10
A novel endoplasmic reticulum dependent IFN-driven signal transduction pathway is critical for the suppression of tumor growth
Dhan V Kalvakolanu
Greenebaum comprehensive cancer center, Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, United States
Tu-P14-11
Treatment with heterodimeric IL-15 promotes effector T cell infiltration into several tumor types
Cristina Bergamaschi1, Konstantinos Dimas2, Bethany Nagy1, 2, Shawn M. Jensen3, Bernard A. Fox3, Barbara K. Felber1, George N. Pavlakis2
1Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, United States, 2Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, United States, 3Robert W Franz Cancer Research Center, Earle A Chiles Research Institute, Providence Cancer Center, Providence Portland Medical Center, Providence, United States
Tu-P14-12
Exosomal NAP1 derived from oral cancer cells enhances the cytotoxicities of NK cells
Wantao Chen1, 2, Yingnan Wang1, 2, Jianjun Zhang1, 2, Xing Qin1, 2
1Department of Oral and Maxillofacial-Head and Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai, China
Tu-P14-14
Targeting the IL-7R pathway in leukemia
Scott Durum1, Julie Hixon1, Emilee Senkevitch1, Sarah Cramer1, Joao Barata2, Scott Walsh1, Wenqing Li1
1National Cancer Institute, National Instiutes of Health, Frederick MD, United States, 2University of Lisbon, Lisbon, Portugal
Tu-P14-15
In-vitro production of VEGF from bone marrow separated CD38+ and CD38- cells in multiple myeloma patients
Vladimir Jurisic1, Katarina Mirjacic-Martinovic2, Ana Radovanovic2, Tatjana Srdic-Rajic2, Olivera Markovic3, Milica Radojkovic4, Gordana Konjevic2
1University of Kragujevac, Faculty of Medical Sciences,, Kragujevac, Serbia, 2Institute of Oncology and Radiology, Belgrade, Serbia, Belgrade, Serbia, 3Clinical Hospital Center "Bezanijska kosa", Belgrade, Serbia, Belgrade, Serbia, 4Department of Haematology, Clinical Hospital Centre Dragisa Misovic, Belgrade, Serbi, Belgrade, Serbia
Tu-P14-16
Loss of p53 unleashes STAT2 to acquire oncogenic activity to promote migration and invasion of colon tumor cells
Ana Gamero, Kevin P Kotredes, Sruthi Gohimukkula, Aliza Abezis, Alexandra Afanassiev
Temple University Department of Medical Genetics & Molecular Biochemistry, Philadelphia, United States
Tu-P14-17
Targeting the BAFF receptor TACI in Chronic Lymphocyte Leukemia
Beatriz Garcillan1, William Figgett1, Saulep-Easton Damien2, Carlo Croce3, Constantine Tam4, Fabienne Mackay1
1Department of Microbiology & Immunology School of Biomedical Sciences University of Melbourne, Parkville, Australia, 2Department of Immunology Monash University, Prahran, Australia, 3Department of Molecular Virology, Immunology and Medical Genetics The Ohio State University, Columbus, United States, 4Department of Haematology Peter MacCallum Cancer Centre Victorian Co-operative Cancer Centre, Parkville, Australia
Tu-P14-18
5-fluorouracil-induced neutrophilic chemokine expression in tumor cells is associated with accelerated lung metastasis of breast cancer
Soichiro Sasaki, Tomohisa Baba, Naofumi Mukaida
Div. Molec. Bioregulation, Cancer Res. Inst., Kanazawa Univ., Kanazawa, Ishikawa, Japan
Tu-P14-19
NK cells control tumor-promoting function of neutrophils
Keisuke Ogura1, Marimo Sato-Matsushita2, Takashi Hori3, Yoichiro Iwakura4, Hideaki Tahara2, Ikuo Saiki1, Yoshihiro Hayakawa1
1Division of Pathogenic Biochemistry, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan, 2Department of Surgery and Bioengineering, Institute of Medical Science, University of Tokyo, Tokyo, Japan, 3Department of Diagnostic Pathology, Toyama University Hospital, Toyama, Japan, 4Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Chiba, Japan
Tu-P14-20
Low-dose HMGN1 synergistically enhances anti-tumor immunity in CD4 depleting antibody-treated mice
Chang-Yu Chen, Satoshi Ueha, Shoji Yokochi, Yoshiro Ishiwata, Haru Ogiwara, Shungo Deshimaru, Kouji Matsushima
Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Tu-P14-21
The role of tumor cell-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) in the progression of 4T1 murine breast cancer
Teizo Yoshimura, Kaoru Nakamura, Chunning Li, Miwa Sato, Akihiro Matsukawa, Masayoshi Fujisawa
Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
Tu-P14-22
The characteristics of cancer stroma in the development of scirrhous gastric cancer.
Kazuo YASUMOTO1, Atsuhiro KAWASHIMA2
1Dept. of Medical Oncology, Kanazawa Medical University, Kanazawa, Japan, 2Dept. of clinical Laboratory Kanazawa Medical Center, Kanazawa, Japan
Tu-P14-23
Prostate cancer progression mechanism via CCL5 within microenvironment of prostate cancer bone metastasis
Satoko Urata, Kouji Izumi, Atsushi Mizokami
Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
Tu-P14-24
Plasmacytoid dendritic cells involve the effect of endocrine disruptor Nonylphenol on endometriosis in murine models
Pooja Sharma1, Yu Chang1, 2, Eing-Mei Tsai1, 3, Jau-Ling Suen1
1Graduate Institute of Medicine,College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 2Department of Obstetrics and Gynecology, E-Da Hospital, Kaohsiung, Taiwan, 3Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
Tu-P14-25
The effect of AGP on tumor proliferation via macrophage activation
Yukio Fujiwara, Chang Pan, Yoshihiro Komohara, Motohiro Takeya
Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Tu-P14-26
Interleukin 1 receptor antagonist (IL-1RA) expression is progressively lost in oral dysplasia and oral squamous cell carcinoma but the phenotypic consequences are not clear
Sven Niklander1, 2, Hannah Crane1, Dan Lambert1, Keith Hunter1
1Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield., Sheffield, United Kingdom, 2Department of Oral Pathology and Oral Surgery, Dentistry Faculty, Universidad Andres Bello, Viña del Mar, Chile
Tu-P14-27
A critical role of IL-27 in controlling tumor-associated regulatory T cells
Yeonseok Chung1, 2, Young Jun Park1, 2
1Laboratory of Immune Regulation, College of Pharmacy, Seoul National University., Seoul, Korea, Republic of (South), 2BK21 Plus program, Seoul, Korea, Republic of (South)
Tu-P14-28
gamma-Aminobutyric acid alleviates progression of renal inflammation and injury in the Vhlh gene-knockout mice
Hsun-Yi Huang1, Tien Hsu2, Bi-Fong Lin1
1Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan, 2Department of Biochemical Sciences and Engineering, National Central University, Taoyuan, Taiwan
Tu-P14-29
Robust synergy in the anti-tumor effects of a systemically administered low dose of the alarmin HMGN1 and anti-PD-L1 antibodies
Shoji Yokochi, Yoshiro Ishiwara, Chang-Yu Chen, Satoshi Ueha, Satoru Ito, Kouji Matsushima
Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Tu-P14-30
A pivotal region for FROUNT-mediated chemotactic signaling that is shared by inflammatory chemokine receptors CCR2 and CCR5
Etsuko Toda1, Yuya Terashima1, Sosuke Yoshinaga2, Hiroaki Terasawa2, Kouji Matsushima1
1Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan, 2Department of Structural BioImaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
Tu-P14-31
FROUNT is a novel target to control chemotactic response of tumor-associated macrophage
Yuya Terashima1, Etsuko Toda1, Meiji Itakura2, Kazuhiro Okumura3, Hiroki Nagase3, Kouji Matsushima1
1Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Japan, Bunkyo-ku, Japan, 2Department of Thoracic Disease, Chiba Cancer Center, Chiba, Japan, 3Chiba Cancer Center Research Institute, Chiba, Japan
Tu-P14-32
Analysis of overlapping CD8+ T cell clonotypes between organs reveals changes in the T cell receptor repertoire after anti-CD4 antibody cancer immunotherapy
Hiroyasu Aoki1, Satoshi Ueha1, Shigeyuki Shichino1, Haru Ogiwara1, Shinichi Hashimoto1, 2, Kazuhiro Kakimi3, Satoru Ito4, Kouji Matsushima1
1Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Laboratory Medicine, Kanazawa University, Ishikawa, Japan, 3Department of Immunotherapeutics, The University of Tokyo Hospital, Tokyo, Japan, 4IDAC Theranostics, Inc., Tokyo, Japan
Tu-P14-33
Aspirin ameliorates inflammatory microenvironment by breaking the crosstalk between macrophages and breast cancer cells
Chia-Chien Hsieh, Chih-Hsuan Wang
Nutritional Science and Education, Department of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan
Tu-P14-34
Inhibition of Nr4a receptors breaks Treg-mediated suppression of anti-tumor immunity
Sana Hibino, Akihiko Yoshimura
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
Tu-P14-35
Epithelial-mesenchymal transition retards IFN-γ signaling in epithelial cancers
Po-Chun Tseng1, Chia-Ling Chen2, Cheng-Chieh Tsai3, Chiou-Feng Lin1, 4
1Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 2Translational Research Center, Taipei Medical University, Taipei, Taiwan, 3Department of Nursing, Chung Hwa University of Medical Technology, Tainan, Taiwan, 4Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
Tu-P14-36
Induction of chemokines and chemokine receptor of glioblastoma infected with HCMV
Masaya Takemoto1, Hidetaka Sadanari1, Tohru Daikoku1, Naofumi Mukaida2, Tsugiya Murayama1
1Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan, 2Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
Tu-P14-37
Antitumor effect of trsan-scirpusin A in colorectal cancer cells
Eun Hye Hong, Jea-Hee Ahn, Jae-Won Jo, Hyun-Jeong Ko
kangwon university, Chuncheon-si, Korea, Republic of (South)
Tu-P14-38
TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and metastasis
Xing Qin1, Ming Yan1, Jianjun Zhang1, Wantao Chen1, 2
1Department of Oral and Maxillofacial-Head & Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,639, Zhizaoju Road, Shanghai 200011, China, Shanghai, China, China, 2Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai, 200011, PR China., Shanghai, China, China
Tu-P14-39
Characterizing the role of IRF8 in Chronic Myelogenous Leukemia Rho-Gef domain variants
Amy Michelle Pitler, Tinghui Hu, Bryan Ciccarelli, Ian P Whitehead
Department of Microbiology & Molecular Genetics, Rutgers University New Jersey Medical School, Newark, NJ, United States
Tu-P14-40
Rb inactivation enhances tumor progression by elevating CCL2 expression.
Fengkai Li1, Shunsuke Kitajima1, 2, Naofumi Mukaida3, Chiaki Takahashi1
1Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan, 2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States, 3Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
Tu-P14-41
Ganoderma formosanum polysaccharides enhance antitumor immune responses and downregulate myeloid-derived suppressor cells in mice bearing CT26 colon adenocacinoma cells
Jhe-Yu Yang, Chun-Jen Chen
Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan
Tu-P14-42
Niclosamide is a poptential therapeutics for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction
Sung Yong Ahn1, 2, Nam Hee Kim1, Kyungro Lee3, 4, Yong Hoon Cha1, Ji Hye Yang1, So Young Cha1, Eunae Sandra Cho1, Yoonmi Lee1, Hyun Soo Cho4, Yoon Jeon4, Young Su Yuk1, Kyoung Tai No3, 4, Hyun Sil Kim1, Ho Lee5, Jiwon Choi3, Jong In Yook1
1Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul, Korea, Republic of (South), 2Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea, Republic of (South), 3Bioinformatics and molecular Design Research Center, Yonsei University, Seoul, Korea, Republic of (South), 4Department of Systems Biology and Division of Life Science, Yonsei University, Seoul, Korea, Republic of (South), 5Graduate School of Cancer Science and Policy, Research Institute, National Cancer Center, Seoul, Korea, Republic of (South)
Tu-P14-43
Glial galectin-9 plays a novel role in hypoxic tumor environment
Chi Young Chang1, Seungtae Baek1, 3, Hyung-Seok Kim1, Sae-Bom Jeon1, Randall S. Johnson2, Eun Jung Park1, 3
1Immunotherapeutic Branch, National Cancer Center, Goyang, Korea, Republic of (South), 2Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3EG Cambridge, United Kingdom, 3Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea, Republic of (South)