Cytokines 2017

19:10 - 21:00

Poster Session 6 “Cytokines in mucosal immunity”

Room: Ishikawa Ongakudō Interchange Hall

Poster Session

Tu-P6-1

TREM-1-dependent M1 polarization restores intestinal epithelium upon DSS-induced colitis by activating IL-22-producing innate lymphoid cells

Nien-Jung Chen, Fu-Chen Yang

Institute of Microbiology and Immunology School of Life Sciences National Yang-Ming University, Taipei, Taiwan

Tu-P6-2

Investigating the roles of IFNγ and IFNγ-stimulated GTPases during Legionella pneumophila replication in alveolar macrophages and monocyte-derived cells

Chao Yang^{1, 2}, Shivani Pasricha², Sze Ying Ong², Andrew Stephen Brown^{1, 2}, Junya Yamagishi³, Chihiro Sugimoto³, Sammy Bedoui², Ian R. van Driel¹, Elizabeth L. Hartland²

¹Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Vic, Melbourne, Australia, ²Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for infection and immunity, Vic, Melbourne, Australia, ³Global Institution for Collaborative Research and Education, Hokkaido University,, Hokkaido, Japan

Tu-P6-3

Pulmonary macrophage transplantation therapy in Csf2ra gene-deficient mice, a novel clinically relevant model of children with hereditary pulmonary alveolar proteinosis

Takuji Suzuki^{1, 2}, Kenjiro Shima², Paritha Arumugam², Bruce Trapnell²

¹Jichi Medical University, Shimotsuke-shi, Japan, ²Cincinnati Children's Hospital Medical Center, Cincinnati, United States

Tu-P6-4

Role of IFNs in gastro-intestinal mucosal inflammation

Constance McElrath^{1, 6}, Jian-Da Lin², Vanessa Espinosa^{4, 5}, Jianya Peng^{1, 6}, Raghavendra Sridhar^{1, 6}, Orchi Dutta^{4, 6}, Hsiang-Chi Tseng^{2, 6}, Sergey Smirnov¹, Risman Heidi², Marvin Sandoval⁷, Mark Galan², Amariliz Rivera^{3, 4, 5}, Joan Durbin^{2, 4, 5}, Sergei Kotenko^{1, 4, 5}

¹Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers University, Newark, United States, ²Department of Pathology and Laboratory Medicine, Rutgers University, Newark, United States, ³Department of Pediatrics, Rutgers University, Newark, United States, ⁴Center for Immunity and Inflammation, Rutgers University, Newark, United States, ⁵University Hospital Cancer Center, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, United States, ⁶Graduate School of Biomedical Sciences, Rutgers University, Newark, United States, ⁷Department of Pathology, New York University School of Medicine, New York, United States

Tu-P6-5

Type I IFN signaling induces Th17 cells capable of promoting gut-mucosal CTLs following intramuscular vaccination of an adenovirus vector

Masahisa Hemmi¹, Masashi Tachibana¹, Natsuki Fujimoto¹, Masaki Shoji¹, Fuminori Sakurai¹, Kouji Kobiyama^{2, 3}, Ken J. Ishii^{2, 3}, Shizuo Akira^{3, 4}, Hiroyuki Mizuguchi^{1, 2, 5}

¹Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, ²National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka, Japan, ³Immunology Frontier Research Center, Osaka University, Osaka, Japan, ⁴The Research Institute for Microbial Diseases, Osaka University, Osaka, Japan, ⁵Global Center for Medical Engineering and Informatics, Osaka University, Osaka, Japan

Tu-P6-6

Pulmonary administration of Duox2 DNA induces interferon secretion in vivo lung against acute influenza A viral infection

Hyun Jik Kim, Yung Jin Jeon, Ara Jo, Sujin An

Seoul National University College of Medicine, Seoul, Korea, Republic of (South)

Tu-P6-7

Human Plasmacytoid Dendritic Cells bind, become activated by, and respond to Aspergillus fumigatus conidia via surface pattern recognition receptors

Samuel Maldonado¹, Jihong Dai¹, Sukhwinder Singh¹, Shobha Swaminathan², Evelyne Kalyoussef³, Bryan Ciccarelli⁴, Amariliz Rivera⁵, Patricia Fitzgerald-Bocarsly¹

¹Department of Pathology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, United States, ²Department of Medicine, Rutgers New Jersey Medical School, Newark, United States, ³Department of Otolaryngology, Rutgers New Jersey Medical School, Newark, United States, ⁴Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, United States, ⁵Department of Pediatrics, Rutgers New Jersey Medical School, Newark, United States

Tu-P6-8

The Microbiome, Staphylococcus epidermidis in Human Nasal Mucosa can enhance IFN-lambda-related immune responses against influenza viral infection

Seong Il Kang, Doo Hee Han, Yung Jin Jeon, Sujin An, Ara Jo, Hyun Jik Kim

Seoul National University College of Medicine, Seoul, Korea, Republic of (South)

Tu-P6-9

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

Naoki Takemura^{1, 2}, Satoshi Uematsu^{1, 2}

¹Department of Mucosal Immunology, School of Medicine, Chiba University, Chiba, Japan, ²2Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Tu-P6-10

Eosinophil and α-SMA⁺ stromal cell interactions induce a positive feedback loop for fibrosis of the small intestine after abdominal irradiation

Satoshi Uematsu

Department of Mucosal Immunology, School of Medicine, Chiba University,, Chiba, Japan

Tu-P6-11

Toll-like receptor 5-mediated induction of type I interferon is required for mucosal anti-flagellin antibody production

YOU-ME KIM¹, Wondae Kang¹, Areum Park¹, Ji-Won Huh¹, Da-Jung Jung¹, Heung-Kyu Lee²

¹Division of Integrative Biosciences & Biotechnology, Pohang University of Science & Technology, Pohang, Korea, Republic of (South), ²Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of (South)

Tu-P6-12

IFN-λ enhances IgG1 antibody production after intranasal immunization by a TSLP-dependent mechanism

Peter Staeheli¹, Liang Ye¹, Daniel Schnepf¹, Jan Becker¹, Karolina Ebert², Valentina Bernasconi³, Hans A Gad⁴, Yakup Tanriver², Rune Hartmann⁴, Nils Lycke³

¹Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany, ²Institute of Microbiology, Medical Center University of Freiburg, Freiburg, Germany, ³Mucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden, ⁴Department of Microbiology and Genetics, Aarhus University, Aarhus, Denmark

Tu-P6-13

Integrin-linked kinase expression in myeloid cells promotes inflammatory signaling during colitis and enhances colon tumorigenesis.

Afsar U. Ahmed^{1, 2}, Bryan R. G. Williams^{1, 2}

¹The Centre for Cancer Research, The Hudson Institute of Medical Research, Clayton, VIC 3168, Australia, Melbourne, Australia, ²The Department of Molecular and Translational Science, Monash University, Clayton, VIC 3168, Australia, Melbourne, Australia

Tu-P6-14

Mesenchymal causalities in inflammation, immunity and cancer.

George Kollias

President and Director, Biomedical Sciences Research Center ‘Alexander Fleming’, Professor of Physiology, Medical School, University of Athens. Member, Academy of Athens, Vari, Greece

Tu-P6-15

Gut microbiota as a source of signals that trigger spontaneous ocular autoimmunity

Reiko Horai¹, Ryan Salvador¹, Kikuji Itoh², Yingyos Jittayasothorn¹, Yoshinori Umesaki³, Katsuko Sudo⁴, Kenya Honda⁵, Rachel Caspi¹

¹Laboratory of Immunology, National Eye Institute, NIH, Bethesda, United States, ²Bio-Technical Center, Japan SLC, Inc., Hamamatsu, Japan, ³Yakult Central Institute, Kunitachi, Japan, ⁴Tokyo Medical University, Shunjuku, Japan, ⁵Keio University School of Medicine, Shunjuku, Japan

Tu-P6-16

Inhibition of IL-17F signaling promotes commensal microbiota-induced colonic Tregs to suppress intestinal inflammation

Ce Tang¹, Shigeru Kakuta², Yoichiro Iwakura¹

¹Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda-shi, Chiba, Japan, ²Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

Tu-P6-17

Type I and type III interferons display different dependency on MAPKs to mount an antiviral state in the human gut

Megan L Stanifer¹, Kalliopi Pervolaraki¹, Dorothee Albrecht², Lynnsey Renn³, Ronald Rabin³, Steeve Boulant^{1, 2}

¹University Hospital Heidelberg, Heidelberg, Germany, ²DKFZ, Heidelberg, Germany, ³USFDA, Bethesda, United States

Tu-P6-18

STAT2 induced Type I Interferon response promotes susceptibility to Salmonella enterica serovar Typhimurium induced inflammation in the gut

Ana M Gamero¹, Sarah A Tursi², Paul Wilson², Kevin P Kotredes¹, Glenn Rapsinski², Nicole Medeiros², Elisabetta Liverani³, Laurie Kilpatrick³, Cagla Tukel²

¹Temple University Department of Medical Genetics & Molecular Biochemistry, Philadelphia, United States, ²Temple University Department of Microbiology and Immunology, Philadelphia, United States, ³Temple University Lung & Inflammation Center, Philadelphia, United States

Tu-P6-19

Norovirus infection induces inflammatory responses to dietary antigens

Scott B Biering¹, Romain Bouziat^{2, 3}, Reinhard Hinterleitner^{2, 3}, Seungmin Hwang^{1, 3, 6}, Bana Jabri^{2, 3, 4, 5, 6}

¹Committee on Microbiology, University of Chicago, Chicago, United States, ²Department of Medicine, University of Chicago, Chicago, United States, ³Committee on Immunology, University of Chicago, Chicago, United States, ⁴University of Chicago Celiac Disease Center, Chicago, United States, ⁵Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, United States, ⁶Department of Pathology, University of Chicago, Chicago, United States

Tu-P6-20

Beta-defensins inducing by interleukin-17s in oral epithelial cell

Thatawee Khemwong, Hiroaki Kobayashi, Takeaki Sudo, Chihiro Kano, Yuichi Izumi

Department of Periodontology, Tokyo Medical and Dental University, Tokyo, Japan

Tu-P6-21

Expression of DICAM, a novel cell adhesion molecule, is well correlated with inflammation of colonic epithelial cells

Hoyul Lee¹, Eun Soo Kim², Chang Joo Oh³, Byong-Keol Min⁴, Eun Jung Choi⁴

¹Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Medical Center, Daegu, Korea, Republic of (South), ²Department of gastroenterology, Kyungpook National University Medical Center, Daegu, Korea, Republic of (South), ³Research Institute of Aging and Metabolism, Kyungpook National University School of Medicine, Daegu, Korea, Republic of (South), ⁴Department of Biomedical Science, Graduate School, Kyungpook National University, Daegu, Republic of Korea; BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Korea, Republic of (South)

Tu-P6-22

Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis

Sayaka Ishihara¹, Miho Mamiyoda¹, Tsuyoshi Sato¹, Akihiko Nishikimi¹, Makoto Saegusa², Koko Katagiri¹

¹Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan, ²Department of Pathology, School of Medicine, Kitasato University, Sagamihara, Japan

Tu-P6-23

Molecular mechanism of anti-pneumococcal immune responses by Dectin-1

Yukiko Akahori^{1, 2}, Rikio Yabe², Yoichiro Iwakura³, Shinobu Saijo²

¹International University of Health and Welfare, Narita, Japan, ²Medical Mycology Research Center, Chiba University, Chiba, Japan, ³Center for Experimental Animal Models, Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan

Tu-P6-24

CCR6 deficiency impairs IgA production and dysregulates antimicrobial peptide production, altering the intestinal flora

Ya-Lin Lin^{1, 2}, Peng-Peng Ip², Fang Liao²

¹Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan, ²Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

Tu-P6-25

Effector T cell migration from gut immune system

Mizuki UEDA¹, Taiki MORIYA¹, Ryoyo KUSUMOTO^{1, 2}, Yutaka KUSUMOTO¹, Michio TOMURA¹

¹Laboratory of Immunology Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan, ²Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan

Tu-P6-26

STING is a negative regulator of innate immune response in Cryptococcus neoformans infection

Mutsuki Kobayashi, Rikio Yabe, Maki Wakatsuki, Yukiko Akahori, Shinobu Saijo

Medical Mycology Research Center, Chiba University, Chiba City, Japan

Tu-P6-27

Search for an enhancer of IL-10 production in the intestinal macrophages for new therapy against inflammatory bowel disease

Nonoka Wakabayashi, Shusaku Hayashi, Makoto Kadowaki

Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan

Tu-P6-28

Intestinal macrophages function polarization by monosaccharides in mice lacking mucin2.

Kseniya Achasova, Ekaterina Litvinova

The Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia