Lamiaceae Family, with 236 genera and more than 7,000 species is a rich source of structurally diverse terpenoids. The genus hymenocrater represents 9 species in Iran possessing anti-inflammatory, anti-spasm, sedative and anti-emphysema activities in traditional and folk medicine [1]. Except for the essential oil compositions a few phytochemical investigations of this genus plants have been reported so far [2,3]. As part of a project aimed at the discovery of structurally new bioactive metabolites from Iranian hymenocrater, we studied hymenocrater elegans.
Fractionation of the n-hexane extract by a combination of open column chromatography on silica gel and preparative TLC afforded six new pimarane diterpenoids (1-6). Their structures were established on the basis of the extensive spectroscopic analysis, including HRMS, 1D and 2D NMR.
References
[1] Morteza-Semnani K, Saeedi M, Akbarzadeh M. Chemical composition and antimicrobial activity of the essential oil of Hymenocrater elegans Bunge. J Essent Oil Bear Plants 2010; 13: 260-266
[2] Khan S, Ali MS, Ahmed Z, Lateef M, Yousuf S, Ahmad VU, Fatima I, Tareen RB. Sessilifol A and B, Urease Inhibitory Pimarane-type Diterpenes from Hymenocrater sessilifolius. Nat Prod Commun 2017; 12: 1831-1833
[3] Gohari A, Saeidnia S, Mollazadeh K, Yassa N, Malmir M, Shahverdi A. Isolation of a new quinic acid derivative and its antibacterial modulating activity. Daru 2010; 18: 69-73