Lei Huang 1, 2, 3, Tong Peng 2, 3, Yu Li 1, 2, 3, Yunyun He 2, 3, Li Wang 2, 3, Shiyan Zhang 2, 3, Fang Chen 1, 2, 3, Lin Tang 1, 2, 3
1 Institute of New Energy and Low-Carbon Technology, Sichuan University, chengdu
2 National and Local Joint Engineering Laboratory for Energy Plant Bio-Oil Production and Application, Sichuan University, Chengdu
3 Key Laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu
Abstracts
: Phytochemical investigation on the
ethyl acetate
extract of Idesia polycarpa Maxim. leaves led to the isolation of four phenolic glycoside isomers (1-4).
Compound
2
appeared to be new
reported phenolic glycoside, while
compound
1
was the first time isolated fromthe titled species.
Their structures were established by IR, UV, HRESI-MS and 1D and 2D NMR spectroscopies analysis and comparison of spectral data with previously reported data.
The compounds 3 and 4 showed stronger activity of scavenging the DPPH free radical than the other two compounds, while the compounds 1 and 2 showed a significant activity of scavenging the ABTS free radical. Compounds 2 and 4 exhibited stronger
cytotoxicity
against HepG2 cell lines compared to compounds 1 and 3
. Moreover,
compound
3
presented the highest cytotoxicity against MCF cell lines with
IC50 value of
37.17 ± 0.26 μg/mL than
compounds
1
, 2 and 4.
Keywords
: Idesia polycarpa Maxim.; phenolic glycoside isomers;
cytotoxicity
; antioxidant
