Jatropha pelargoniifolia Courb. is a shrub indegenous on the Arabian Peninsula and widely known as “Obab” . The plant has been used in traditional medicine. Sap of the petiole is applied to ulcers, sever skin inflammation and for wound healing [1]. Thus, it was of interest to explore the active constituents and biological importance for titled plant. Previous phytochemical investigation, by our research group, for the biologically-active fractions of J. pelargoniifolia root, resulted in isolation of β-sitosterol, β -sitosterol glucoside , curcusons C&D, naringenin, apigenin, hovetricoside C, cynaroside, linarin,propacin, cleomiscosins A&B and uracil (2). Further extensive chromatographic investigation into other fractions of the titled plant afforded more nine compounds . Two of them were isolated here for the first time from nature and their structures were verified as 6-hydroxy-8-methoxy coumarin-7-O-β-D-glycopyranoside (1) and (3-(2-(methylamino) ethyl)-1H-indol-2-yl) methanol (2). The rest of compounds were found to be indol derivative such as N-methyltryptamine (3), phenylethylamine derivatives, N-methyltyramine (4) hordenine (5), and their salts (6, 7), the latter five compounds have been isolated here for the first time from Euphorbiaceous plants. The remaining two compounds are identified as diterpene congers; spruceanol (8) and jatrophadiketone (9) previously identified in various Jatropha species. The structures of the isolated compounds were unambiguously determined using physical data and different spectroscopic techniques including, HRESIMS, 1D & 2D-NMR. The anti-inflammatory, antinociceptive, antipyretic and antioxidant activities were evaluated for some isolated compounds which are available in good yields and some showed promising activities.
References:
[1]Schmelzer GH, Fakim GA. 2007: Jatropha Pelargoniifolia . Record from Prota4u. Prota plant resources of tropical Africa/ressources v égétales de l’Afrique tropicale, wageningen, Netherlands. 2007.
[2] Aati H, ElGamal A, and Kayser O. 2017: Phytochemical and Biological Investigation of Jatropha pelargoniifolia Root Indigenous to Saudia Arabia. In: GA Basel Switzerland Conference, PMIO;4(S 01): S1-S202, DOI: 10.1055/s-0037-1608189.