The leaves of Artemisia argyi Levl. et Vant have been used as a hemostatic and sedative agent in traditional Chinese medicine [1]. However, there was no research on the secondary metabolites of the roots of A. argyi up to date. Repeated chromatography of EtOAc-soluble fraction from 70% EtOH extract of the roots of A. argyi led to the isolation of a new caffeoylquinic acid, (E,Z)-4,5-di-O-caffeoylquinic acid (1), along with two dicaffeoylquinic acids, (E,E)-4,5-di-O-caffeoylquinic acid (2) and (E,E)-3,5-di-O-caffeoylquinic acid (3), two sterols, 7-ketostigmasterol (4) and 7-ketositosterol (5), and three coumarins, umbeliferone (6), scopoletin (7), and scopolin (8). The structure of the new compound 1 was elucidated by physical and spectroscopic data interpretation.
[1] Yoshikawa M, Shimada H, Matsuda H, Yamahara J and Murakami N. Chemical and pharmaceutical bulletin 1996; 44(9): 1656-1662;
