GA 2018

Presently, docetaxel is used in the treatment of breast, non-small cell lung, prostate and other cancers. However, there exists a significant difference in individual drug sensitivity and toxicity. In this paper, genetic variation of drug metabolism related genes is reviewed. We study correlations between the genetic polymorphisms of CYP450, ABC, SLCO1B3, and GSTs as well as the clinical efficacy and adverse drug reactions of docetaxel in order to provide a theoretical basis for clinically individualized medication.