Gynura procumbens (Lour.) Merr. is a medicinal plant commonly found in tropical Asia countries. Traditionally, it is widely used in many different countries for the treatment of a wide variety of health ailments such as kidney discomfort, rheumatism, diabetes mellitus, constipation, and hypertension [1]. Modern pharmacological research on G. procumbens has shown that it has multiple biological activities, such as antihypertensive, cardioprotective, antihyperglycemic, fertility enhancement, anticancer, antimicrobial, antioxidant, organ protective, and anti-inflammatory activity [2]. However, few studies have focused on the chemical constituents from G. procumbens. In the current work, phytochemical investigation of whole plants of G. procumbens led to the isolation and purification of ten compounds. The structures of these compounds were determined on the basis of their 1H NMR, 13C NMR, and ESI-MS spectroscopic data, and by comparison with those previously reported in the literature, as compounds (1–10): hexacosanoic acid (1), β-sitosterol (2), daucosterol (3), β-stigmasterol (4), 5α-stigmastna-3-one (5) methyl linoleate (6), 1-methoxyhenicosan-1-ol (7), homoorientin (8), kaempferol (9), and eriocitrin (10). It is worth noting that all the ten compounds (1~10) were isolated here for the first time from G. procumbens, and compounds 1, 5-8, and 10 have never previously been reported from Gynura genus .
References. 1. Tan H L, Chan K G, Pusparajah P, et al. Front Pharmacol 2016; 7: 1-14. 2. Hew C S, Khoo B Y, Gam L H. PloS one 2013; 8(7): e68524. Acknowledgements: This work was kindly supported by Foundation of Key Project of Research and Development Program of Jiangxi Province (No. 20171BBH80017 and 20171ACF60009), the Science and Technology Major Project Foundation of Jiangxi Academy of Sciences (2018-YZD1-05 and 2018-YZD2-18), and Science Foundation for Young Doctors of Jiangxi Academy of Science (2016-YYB-07).