The incidence of hyperuricemia is increasing year by year, and it is becoming younger, which brings great burden to family and society. In recent years, Chinese medicine has achieved certain results in the clinical treatment and basic experimental research in hyperuricemia. It has unique advantages, and has become a hot spot in the study of hyperuricemia. Chinese medicine has always had obvious advantages in the treatment of chronic diseases. Simiao pills can clear damp-heat, and 1t is common Chinese patent medicine, which is used to treat hyperuricemia and gouty arthritis. Rats were randomly divided into blank group, model group, benzbromarone group, and Si m iao Pill s group , a total of 4 groups. A hyperuricemia rat model was prepared with yeast extract 10g/(kg · d) combined with adenine 100mg/(kg · d).The rat serum and kidney tissues were collected for 14 consecutive days after successful modeling.The experimental results show that : Simiao Pills could reduce serum uric acid, increase the content of UUA, 24hUUA and UCr, reduce the content of Scr, BUN and XOD activity in hyperacidemia rat, inhibit the expression of URAT1 protein and enhance MRP4 and ABCG2 protein expression in kidney tissue of hyperuricemia rats.Simiao pills can not only inhibit uric acid production, but also promoted uric acid excretion by upregulating the expression of MRP4 and ABCG2 protein in renal tissue.
Keywords: hyperuricemia ; MRP4; ABCG2; URAT1; Simiao pills
Acknowledgements: T he National Natural Science Foundation of China(No. 81273632 )