Citrullination has been a major focus among investigators studying the pathophysiology of rheumatoid arthritis (an autoimmune, inflammatory arthritis), given the high specificity of anti-citrullinated protein antibodies (ACPAs) for this disease.
This talk will discuss findings related to neutrophil and macrophage extracellular traps as potential sources of citrullinated antigens bound by ACPAs, the role of citrulline-containing IgG epitopes as unifying antigens for the two major autoantibody types in rheumatoid arthritis (ACPAs and rheumatoid factors), and the contributions of two citrullinating enzymes, peptidylarginine deiminase 2 and 4, in murine models of rheumatoid arthritis.