Emetophobia is a specific phobia characterized by an intense fear of nausea and vomiting. Emetophobic individuals interpret disgust sensations as threatening stimuli [AZ1] [AZ2] during as a sign of impending vomiting, which triggers increased anxiety, thereby increasing their arousal levels. Disgust plays a crucial role in both the development and the maintenance of emetophobia. Contamination sensitivity offers a relevant framework for understanding the association between emetophobia and disgust: contact with objects perceived as having a high potential for contamination may be experienced as threatening by emetophobic people. In our study, we investigated the physiological responses relevant to emetophobia elicited by disgusting stimuli. Within our experimental model, we used disgust as a threat-related stimulus, given its central role in the development of specific phobias including emetophobia. Participants (N=40) completed the EmetQ-13 and the SPOVI questionnaires assessing emetophobia severity. Subsequently, they viewed either a 10-minute neutral or a disgust-inducing video. During the vide, we measured skin conductance and heart rate variability to detect increases in arousal level. Our findings suggest that the manipulation was successful, participants exposed to disgusting stimuli reported higher levels of disgust. More importantly, an intense fear of vomiting is associated with heightened arousal responses as evidenced by faster skin conductance responses (SCR) and higher heart rate variability. Participants reported higher level of disgust based on their subjective ratings, this was also reflected in the physiological measures. These findings highlight the clinical relevance of disgust in emetophobia and underscore the importance of considering this association when developing therapeutic protocols.