Action control relies on the automatic binding and retrieval of perceptual and motor features into so-called event files. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neurostimulation method that modulates neurotransmitter systems implicated in gain control, particularly the locus-coeruleus–noradrenaline and GABAergic systems. According to the gain control account, taVNS enhances neural signal-to-noise ratio, thereby amplifying the processing of task-relevant information. Building on this approach, we investigated whether taVNS alters the strength of stimulus–response (S-R) bindings. Healthy participants (N = 69) performed a stimulus-response binding task while receiving active or sham taVNS in a single-blind design. Behavioral indices of reaction times revealed significantly stronger S-R binding effects under active compared to sham stimulation, indicating enhanced integration and/or retrieval of event files. These findings provide evidence that taVNS can modulate core processes of action control, likely via gain-related modulation of perceptual and response feature weighting.