Growth in large loads, particularly data centers, is driving dramatic change to power systems planning in multiple regions around the world. Their unprecedented concentration in power demand, high but uncertain growth, and dynamic demand profiles create unique risks to system reliability and affordability. This presentation will examine how these planning challenges are occurring in the United States and describe mitigation options for these risks. It will show leading load forecasting practices that could reduce uncertainties. Tariffs and other regulatory or policy options have also been rapidly developed to protect other customers from the potential cost impacts. The presentation will also explore flexibility from the loads themselves--through load curtailments, load shifting, and associated generation or storage (e.g., bring-your-own-capacity) options--that can further mitigate risks and enable large loads to be grid assets rather than liabilities. The presentation will summarize work from the Energy Systems Integration Group's Large Loads Task Force, which convened stakeholders across the power systems and data center industries to identify practical solutions and develop harmonized practices that ensure reliable and efficient grid integration of large loads.