The modern society is undergoing a process of massive datafication [1]. The availability of new digital data sources represents an opportunity for Statistical Offices (SO) to complement traditional statistics as well as to produce novel statistical products with improved timeliness and relevance. However, such opportunities come with important challenges in almost every aspect – methodological, business models, data governance, regulation, organizational and others. The new scenario calls for an evolution of the modus operandi adopted by SO also with respect to privacy and data confidentiality, that is the focus of the present contribution. We propose here a discussion framework focused on the prospective combination of advanced Statistical Disclosure Control (SDC) methods with Secure Multi-Party Computation (SMC) techniques.