The European system of interoperable Statistical Business Registers (ESBRs) project is one of the ESS 2020 Vision Implementation Projects aimed at improving the quality of statistics in the EU. In the ESBRs, Eurostat and the European Statistical System (ESS) partners cooperate by exchanging and integrating micro data on legal units, control relationships between legal units and enterprises to achieve a complete view on the structure and activities of multinational groups operating in the EU. The need to exchange statistical information on multinational groups comes from the fact that each national statistical office alone is unable to derive a complete and correct picture from its national administrative sources. They can observe only a 'truncated' view of the multinational groups for the legal units that are resident on their territory and some cross border relationships, while information about non-resident legal units and the control chain outside its territory is usually not reachable. The integration process is managed centrally at Eurostat and takes place in the EuroGroups Register system (EGR 2.0 [1]). The national statistical business registers send their input data that cover EU legal units, while other commercial sources are used to cover non-EU legal units. In addition, national statisticians in different NSIs can improve the results automatically generated by the EGR. In particular, they further integrate statistical information obtained by manually profiling some of the largest and most relevant multinational groups in the EU. The result of European profiling is subsequently integrated into the EGR and constitutes another important pillar of the whole integration process in the ESBRs. This step of the ESBRs data integration process generates additional challenges because the view adopted in European profiling is top down, while the EGR integration process works bottom up. The output of this integration process is a statistical frame, called the EGR global frame, containing the consolidated legal structure of the multinational groups in the EU and their statistical units. The EGR global frame is sent back to the national statistical institutes (NSIs). The feedback can be used at national level to be integrated back into the national statistical business registers to improve and complete their partial view on the multinational groups. Ultimately, the EGR global frame should function as the coordination tool for all ESS statisticians to improve the quality and consistency of data measuring the activities of the multinational groups across the EU.