IMF2017

A remotely controlled dynamic process has been developed for manipulation of targeted biological cells using magnetoelectric nanocomposites which are core-shell nanoparticles comprised of single crystalline ferromagnetic cores (CoFe2O4) and ferroelectric crystalline thin film shells (BaTiO3). We demonstrated that these nanocomposites behaves as a unique family of inorganic magnetoelectric nanorobots (MENRs), which can be controlled remotely by ac or dc magnetic fields for dynamic cellular manipulation including cell targeting, permeation, and transport. MENRs performs these functions via localized electric periodic pulse generation, local electric-field sensing, or thrust generation and acts as the unique tool for remotely controlled dynamic cellular manipulation. We have designed a custom build systematic setup to accurately examine the MENRs-cellular interaction and performed experiments in microvascular structured microfluidic chamber (MSMC) with complex junctions and variable pressure gradient corresponding to vascular environment. The details of these MENRs and their performance will be presented in this paper.