As signal acquisition part of equipment, piezoelectric vibration acceleration sensor is used widely in the practical engineering. There are lots of precision circuits in the sensor. So, if there is a big electromagnetic pulse in the environment, the electromagnetic pulse will be coupled into the circuits in the sensor through power cords and data cords. It’s important to protect the sensor from the damage of electromagnetic pulse. The electromagnetic pulse protection circuits of power cords and data cords are researched in this paper. The piezoresistor and TVs are used as transient components in the protection circuits. Through optimization grouping, the optimized protection circuit is found. The simulation and experimental results show that the protection circuits proposed in this paper can protect the sensor very well. The protection circuits’ design method can be referenced in the engineering practice.