The main research areas of the lab PGNM (Pathophysiology and Genetics of Neuron and Muscle) are focused on basic biological mechanisms at the molecular, cell, tissue and organism levels to better understand their alterations in human pathologies and to uncover new therapeutic approaches. Our laboratory is an asset to tackle scientific and medical issues that are crucial for our understanding of the biology of the nervous and muscular systems.

In this environment, the iPSC PGNM technical platform manages equipment and expertise in culturing and manipulating human induced pluripotent stem cells (hiPSC). We offer a variety of trainings either internal training or through CNRS Formation Entreprise (CFE) covering hiPSC culture, quality control, genome editing, differentiation and 3D hiPSC-derived models.

At the iPSC PGNM technical service, gene editing and directed differentiation of hiPSC cell lines—including our primary control line, AG08C5/PGNMi001-A, and various patient-derived iPSCs—are performed to generate different cell types, such as neurons (motor neurons, sensory neurons, etc.), cardiomyocytes, chondrocytes, and hematopoietic stem cells (Badja et al., 2014; Gonnot et al., 2023; Musawi et al., 2023; Halegua et al., 2025). We are also developing 3D cultures of differentiated cells from hiPSC.