The United States and Europe powers are increasingly converging in their diagnosis of the security challenges that emanate from the Indo-Pacific. Both sides of the Atlantic now deem China as a strategic rival and point to the need to respond to the negative consequences of its assertion of power in the region. This primarily reflects a significant change in European strategic thinking. This paper explains the domestic drivers behind the changing strategic assessments in major European powers such as France, Germany and the United Kingdom as it reviews their key strategic policy documents. It then assesses the capabilities of the said states in order to ascertain the extent to which cooperation with the United States in the Indo-Pacific is possible by considering the prospects of bilateral and minilateral cooperation with the US, as well as in the context of US-EU relations and within the NATO alliance. The paper argues that in the near to medium term, there is plenty of scope for functional cooperation on the development of regional infrastructure, as well as a stepped-up involvement in the relevant diplomatic frameworks and fora. At the same time, while military cooperation is a policy area that has traditionally seen deepest integration between the two sides of the Atlantic, it is going to be more challenging in the context of the Indo-Pacific given the myriad of domestic constraints on the European side in particular.