Confronted with the Covid-19 pandemic, national governments implemented various policies to contain the virus. This paper studies the effects of government opposition on willingness to comply with the obligation to wear masks, social distancing, and lockdowns measures. We use original survey data examining attitudes during the pandemic in 11 European countries. We find that government opposition decreases compliance, particularly when the costs of compliance increase. Moreover, our findings indicate that right-wing respondents oppose most measures even when costs are minimal. Finally, we show that political motivations trump respondents’ risk perceptions and economic motivations.