10:15 - 12:15
Parallel sessions 4
+
10:15 - 12:15
Wed-S6
Room: Waalsprong 1+2
Chair/s:
Veronica Lee Flores, Joost X Maier
Benign taste experience during development impacts rodent taste learning and processing in adulthood.
Wed-S6-004
Presented by: Veronica Flores
Veronica FloresBailey Tanner
Furman University
Sensory experience modulates perception and learning of new and familiar stimuli. For example, in taste learning, benign experience with a taste decreases the associativity of that same taste (conditioned stimulus; CS) with a future conditioned taste aversion (CTA); a phenomenon known as latent inhibition. Recently, we have shown that even familiarity with tastes other than the CS can influence later learning toward novel tastes (Flores et al., 2016). These data suggest that benign taste experiences, are in fact only seemingly benign and can modulate future taste learning. Given that benign taste experiences are ubiquitous in everyday life, it is important to consider how experiences during developmental learning might impact future taste processing. Here, we test the hypothesis that early life experience with sucrose will cause latent inhibition of future aversion learning of sucrose paired with lithium chloride. We expect that latent inhibition of learning will generalize to equally palatable concentrations of fructose and saccharin. Lastly, we test the hypothesis that latent inhibition will be correlated with higher perceptual thresholds of sucrose in adulthood. We test the above using a CTA paradigm in Long Evans Rats who experienced sucrose during different developmental periods (gestation, lactation, or weaning). A one-way ANOVA shows that early exposure to sucrose does not induce latent inhibition of CTA learning later in life, and instead leads to stronger CTA learning in adulthood. Additionally, aversions generalized to fructose and saccharin and generalization strength correlated with lower thresholds for sucrose during adulthood. These findings begin to characterize the impact of incidental taste experiences early in life on future taste learning in adulthood within rodents. This work was supported by the South Carolina, IDEA Networks of Biomedical Research Excellence, Faculty Fellow Award through the National Institute of General Medical Sciences.