Mice rely on the sense of smell for all basic life activities, including foraging, social recognition, mate choice, defining territory, and more. This central role that olfaction plays in physiology served as the evolutionary driving force for the extraordinary development of the murine olfactory system, making mice a perfect model organism to unravel the mechanisms underlying olfactory system physiology. The study of the mouse sensory system enabled researchers to uncover fundamental as well as complex aspects of chemoreception that were later translated to other organisms like humans. We aim to highlight recent developments in mouse olfactory research and will present diverse research topics spanning from peripheral to central olfactory pathways.