Animal studies have demonstrated that the olfactory bulb (OB) is a key node of the olfactory system and the list of olfactory tasks in which it is implicated keeps growing. However, until recently, no technique existed that allowed non-invasive measures of signal from the OB in awake and healthy humans. In this talk, I will outline the development, validation, and implementation of a new method, the electrobulbogram (EBG), that enable non-invasive measures from the human OB in healthy humans while they are processing odors. In addition, I will summarize results from our recent studies where we used the EBG method to assess the role of the human OB in forming our odor perception as well as its communication with piriform cortex. I will argue, akin to some animal models, that one of the main roles of the human OB is to sequentially process odor valence, with a temporally privileged access to negative odors. Finally, I will review our ongoing work to use the EBG measure as a potential tool for early Parkinson’s disease detection.