Introduction: The pathophysiology and biogenetics of global gut dysmotility has yet to be fully defined. This abstract highlights the results of an observational study that is conducted at a tertiary center with high referral volume. The aim of this study is to define the clinical, neuropsychiatric, and socioeconomic status of this unique patient population.

Methods: A total of 175 patients were referred to our program with global gut dysmotilty for possible surgical management including reductive surgery and/or transplantation. The diagnosis of global gut dysmotility was made by exclusion of mechanical bowel obstruction, capsule endoscopy, and sitz marker testing.

Results: Most patients were female adults with a total mean age of 36 + 14 (range: 5-70). The medical and surgical histories were significant for oral intolerance, constipation, abdominal pain, orthopedic procedures and cosmetic surgery. There was a common association between the disorder, bariatric surgery, and congenital anomalies. The major neuropsychiatric disorders were anxiety (70%), depression (64%), behavioral disorders (35%), abuse (32%), PTSD (15%), suicidal ideations (13%), and bipolar disorder (7%). The syndrome was associated with autonomic dysfunction (72%), autoimmunity (19%), and mitochodrial disease (3%). Most of the socioeconomic milestones including marriage, education, occupation, and daily activities were severely impaired.

Conclusion: The described herein clinical features may be a valuable tool to assess the spectrum of the disorder, guide therapy, and selection criteria for transplantion.