Introduction: Intestinal/multivisceral transplantation (IT/MVT) is the gold standard treatment for patients with intestinal failure and complications related to total parenteral nutrition, gastrointestinal inoperable indolent tumors, or diffuse portal trombosis.

Methods: Since 2004 we performed 7 full multivisceral transplantation between December 2014 and May 2018. Indications for transplantation were multivisceral thrombosis (n=5) and desmoid tumours (n=2). Immunosuppression was based on induction with alemtuzumab (followed by tacrolimus and steroids) in the first period and infliximab and basiliximab (followed by with tacrolimus and steroids) in the last case.

Results: Four patients are alive. All these patients are without parenteral nutrition. Mortality rate was 43% due to sepsis in 2 cases and in 1 case to cardiac faillure in the first day after transplantation. In all patients we diagnosed acute cellular rejection. Graft-vs.-host disease was seen in 1 case.

Conclusion: Intestinal transplantation is a suitable treatment for highly selected patients with intestinal failure who meet specific listing criteria.