Duplex stainless steel (DSS) is considered a difficult-to-machine material due to the high tool wear and short tool life as a result of the strain hardening and relatively low thermal conductivity of this material. This paper presents extensive experimental work to show wear rate, wear mechanism and resulting surface quality of machined parts, and tool life in the machining process of X2CrNiMoN22-5-3 (1.4446) duplex stainless steel under high-pressure coolant (HPC) condition with various pressure and their comparison with flood coolant. Experimental results illustrate that pressure in high-pressure coolant applications plays an important role in the tool wear mechanism and tool life. However, its role is much critical when cutting speed is varied. It was observed that in the runs where under high-pressure coolant supply and several cutting speed conditions (80, 120, 160 m/min), the maximum flank wears decreased %22.2, %27.1, %22, respectively. Also, surface roughness and surface topography results compared each other after materials were machined over 6000 mm.