In traditional response precueing research, cues direct attention to a relevant subset of potential stimuli and their responses, allowing to prepare more effectively. While most studies focused on visual-spatial targets and manual responses, we designed a novel multimodal response precueing paradigm using visual and auditory precues and targets with manual or vocal responses. In this paradigm, the target modality – response modality pairing was fixed. Precues could either indicate the target modality (visual vs. auditory) and thus the response modality; or indicate the relevant target location (left or right), and thus a left or right response. We aimed to investigate whether precueing a response modality (e.g., left and right auditory precues indicating an auditory target, and thus a vocal response) would result in similar performance as precueing a response location (e.g., left auditory and left visual precue indicating a left response –spatial precue). Performance in both conditions was compared to neutral precues. As expected, modality precues consistently led to better performance than neutral precues, while spatial precues displayed a speed-accuracy tradeoff. Unexpectedly, however, the modality precue produced a larger preparation benefit than the spatial precue. We suggest that priming the response modality enables faster and more automatic mapping between the target and its response. However, performance enhancement still occurs due to the difficulty of quickly preparing for a verbal response code of the effector modality. In contrast, we propose that priming the effector side, when there is uncertainty about which response-modality to use, lead to confusion and decreased performance.