This study focuses on assisting Toxic and Chemical Substances Bureau (TCSB), EPA,Taiwan to conduct a study on building a risk communication model between TCSB and chemical industry on toxic and highly concerned chemical substances. We will demonstrate the best practices of risk communication on the safe use of chemicals in Taiwan. In order to build up risk communication models between TCSB and chemical industry, we compared Taiwan’s toxic and chemical risk management and risk communication system with those in US, Canada, and EU. Four types of communication situations have been adopted and named as "normal situation", "uncertainty risk", "controversial risk", and "crisis situation." The first version of “Guideline on Risk Communication of the Use of Toxic and Chemical Substances” has been compiled as a reference manual of risk communication for TCSB under various risk situation. Four steps in risk communication process are to identify issues, risk communication preparing, to perform communication, and to evaluate risk communication performance. Respectively, individuals and the public, media and stakeholder groups are the three groups for communication objects. It’s crucial to keep momentum about the risk communication with different stakehoders, and learning communication skills with the expertise worldwide.