The rapid pace of innovation has created a constantly growing and shifting digital landscape of health information that people seek to navigate. This landscape creates various opportunities for knowledge exchange and benefits for the users, but also risks harm for individuals, groups and entire communities. As the digital society continues to evolve, new opportunities and potential risks will continue to emerge, both on- and offline, in particular through rapid technological advance. Together with benefits, new uncertainties and risks that digital society poses to the individual’s health and to society need to be thoroughly discussed, understood and managed. The aim of the symposium is to present findings from the research network “Navigating Knowledge Landscapes”, which develop international and inter- and transdisciplinary collaborations, and explores the area of online and offline communication and distribution of health and biomedical information and knowledge. The particular objective of the symposium is to advance the understanding of uncertainty and risk when navigating across the (digital) health knowledge landscapes, and to critically analyse different approaches of governance in this landscape.