Rice fermented liquid as an alternative for water that retains skin moisture and its application for cosmetics
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Presented by: Zheng Zhou
Introduction:
Fermentation technology is used in various applications such as foods, detergents, medicines in our lives. In particular, fermented foods have a very long history, and the ingredients produced by fermenting plants with microorganisms are delicious, good for health, and have various effectiveness such as improving storage stability. Among them, it has long been known that the combination of rice and yeast are the best for sake brewing, which is a traditional Japanese fermentation technology. We have tried to develop the rice fermented liquid because it is well compatible with the skin when applying. So far, it has confirmed that 2-ketoglutaric acid (2-KG), which is efficiently produced by yeast fermentation of rice, has promoting effects on proliferation of epidermal keratinocytes and on the expression of mRNA of factors (filaggrin, SPT, involucrin) related to the moisturizing and barrier function in in vitro tests (reported at the IFSCC Mexico conference 2021). In this study, in order to confirm the efficacy of rice fermented liquid as a cosmetics ingredient, we have conducted a human clinical trial with continuous use of a lotion containing the liquid.
Methods:
The double-blind, placebo-controlled, left-right randomized clinical trial was carried out. A lotion formulation including 94.5% rice fermented liquid or a blank was topically applied to the left or right half face in healthy volunteers (n=24) twice daily for 8 weeks. Skin hydration was measured using Corneometer CM825. Transepidermal water loss (TEWL) was measured using Vapometer SWL5001JT. The skin elasticity was measured using Cutometer MPA580. Facial analysis was then performed using VISIA-Evolution.
Results:
Continuous application of the lotion containing rice fermented liquid for 8 weeks significantly increased the stratum corneum water content and the number of skin textures as compared with the blank lotion, and TEWL also tended to decrease. In an age-stratified analysis, a significant improvement in R0 values (skin distensibility) by the lotion containing rice fermented liquid was found in subjects aged over 30 years and in those under 50 years.
Discussion and Conclusion:
It was demonstrated that rice fermented liquid, which makes up the majority for a test lotion, is useful as a functional water having the ability to retain skin moisture.
Fermentation technology is used in various applications such as foods, detergents, medicines in our lives. In particular, fermented foods have a very long history, and the ingredients produced by fermenting plants with microorganisms are delicious, good for health, and have various effectiveness such as improving storage stability. Among them, it has long been known that the combination of rice and yeast are the best for sake brewing, which is a traditional Japanese fermentation technology. We have tried to develop the rice fermented liquid because it is well compatible with the skin when applying. So far, it has confirmed that 2-ketoglutaric acid (2-KG), which is efficiently produced by yeast fermentation of rice, has promoting effects on proliferation of epidermal keratinocytes and on the expression of mRNA of factors (filaggrin, SPT, involucrin) related to the moisturizing and barrier function in in vitro tests (reported at the IFSCC Mexico conference 2021). In this study, in order to confirm the efficacy of rice fermented liquid as a cosmetics ingredient, we have conducted a human clinical trial with continuous use of a lotion containing the liquid.
Methods:
The double-blind, placebo-controlled, left-right randomized clinical trial was carried out. A lotion formulation including 94.5% rice fermented liquid or a blank was topically applied to the left or right half face in healthy volunteers (n=24) twice daily for 8 weeks. Skin hydration was measured using Corneometer CM825. Transepidermal water loss (TEWL) was measured using Vapometer SWL5001JT. The skin elasticity was measured using Cutometer MPA580. Facial analysis was then performed using VISIA-Evolution.
Results:
Continuous application of the lotion containing rice fermented liquid for 8 weeks significantly increased the stratum corneum water content and the number of skin textures as compared with the blank lotion, and TEWL also tended to decrease. In an age-stratified analysis, a significant improvement in R0 values (skin distensibility) by the lotion containing rice fermented liquid was found in subjects aged over 30 years and in those under 50 years.
Discussion and Conclusion:
It was demonstrated that rice fermented liquid, which makes up the majority for a test lotion, is useful as a functional water having the ability to retain skin moisture.