Application of Multiple-light Scatterer to Evaluate the Effect of Different Emulsification Technology on Emulsion Stability
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Presented by: Yu Yu
Introduction: The stability of emulsion is not only controlled by temperature and ingredients, but also affected by the emulsification technology. Turbiscan Lab multiple-light scatterer is an analytical instrument used to vertically scan concentrated systems such as emulsions, suspensions and foams to determine their stability. It can quickly reflect the changing trend of the emulsion system, shorten the stability test period, and speed up the launch of products.
Methods: In this study, two processes of traditional emulsification technology and low-energy emulsification(optimized LEE technology) were used to prepare the same cream. Then we prepared creams with the same formula above by changing the adding method of different active ingredients (bisabolol and sodium sodium hyaluronate) using low-energy emulsification technology. The stability of all the creams prepared by different processes was investigated by multiple-light scatterer.
Results: Compared with the traditional emulsification process, the cream prepared by the low-energy emulsification process had better stability overall, in terms of high temperature text, low temperature text and freeze-thaw text, but the internal particle dispersion uniformity was poor, and its particle size changed more significant under different test conditions. The method of adding bisabolol and sodium hyaluronate before homogenization and participating in high temperature homogenization, the system has good room temperature stability, but poor high temperature and freeze-thaw stability; The method of adding bisabolol before homogenization and participating in high temperature homogenization but adding sodium hyaluronate after homogenization in room temperature, the system has good freeze-thaw stability, but poor room temperature or high temperature stability; The method of adding both bisabolol and sodium hyaluronate at room temperature after homogenization, the system has good high temperature stability, but poor room temperature/freeze-thaw stability.
Conclusion: The effect of different emulsification processes and different ingredient,s adding method on the stability of the system were studied using multiple-light scatterer. Different emulsification technology has different influence on product stability. Compared with traditional evaluation methods, the application of multiple-light scatterer in product stability evaluation can not only obtain the product system change information simply and objectively, but also improve the screening efficiency of formula development and process development.
Methods: In this study, two processes of traditional emulsification technology and low-energy emulsification(optimized LEE technology) were used to prepare the same cream. Then we prepared creams with the same formula above by changing the adding method of different active ingredients (bisabolol and sodium sodium hyaluronate) using low-energy emulsification technology. The stability of all the creams prepared by different processes was investigated by multiple-light scatterer.
Results: Compared with the traditional emulsification process, the cream prepared by the low-energy emulsification process had better stability overall, in terms of high temperature text, low temperature text and freeze-thaw text, but the internal particle dispersion uniformity was poor, and its particle size changed more significant under different test conditions. The method of adding bisabolol and sodium hyaluronate before homogenization and participating in high temperature homogenization, the system has good room temperature stability, but poor high temperature and freeze-thaw stability; The method of adding bisabolol before homogenization and participating in high temperature homogenization but adding sodium hyaluronate after homogenization in room temperature, the system has good freeze-thaw stability, but poor room temperature or high temperature stability; The method of adding both bisabolol and sodium hyaluronate at room temperature after homogenization, the system has good high temperature stability, but poor room temperature/freeze-thaw stability.
Conclusion: The effect of different emulsification processes and different ingredient,s adding method on the stability of the system were studied using multiple-light scatterer. Different emulsification technology has different influence on product stability. Compared with traditional evaluation methods, the application of multiple-light scatterer in product stability evaluation can not only obtain the product system change information simply and objectively, but also improve the screening efficiency of formula development and process development.