Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids, RNA, and DNA. They are derived from endocytic membranes and can transfer signals to recipient cells, thus mediating a novel mechanism of cell-to-cell communication. Liposomes are small artificial vesicles of spherical shape that can be created from cholesterol and natural non-toxic phospholipids. Due to their size and hydrophobic and hydrophilic character, liposomes are promising systems for drug delivery. Exosomes and liposomes have many similarities as they are nanovesicles composed of one lipid bilayer. Exosomes has the advantage of being an endogenous nanocarrier, but it lacks deformation flexibility and has a low yield. On the other hand, liposomes show exceptional flexibility to facilitate various engineering approaches, but lack endogenous functions. The purpose of this work was to develop a new type of liposomes with a unique mixture of phospholipids, similar to naturally occurring exosomes but overcoming their limitations of heterogeneity and low productivity, for therapeutic delivery of bioactive compounds. The evaporate–hydrate method was used to design a hybrid exosome (HE) by fusing exosomes derived from Centella asiatica with liposomes. In addition, hybrid exosomes were prepared using a high-pressure micro-emulsification method using a microfluidizer to form a stable vesicle membrane without affecting the intrinsic properties of natural exosomes and synthetic liposome nanoparticles. To further validate the liposome–exosome fusion, the DLS, turbiscan, rheometer and Cryo-TEM were analyzed. TEM analysis showed that HE were morphologically similar to liposomes, and had an average diameter of less than 200 nm and zeta potential greater than |5| mV. Through the dispersion stability and rheology of these hybrid exosome, stable form of HE could be known. These results can help develop efficient nanocarriers as a way to show the potential of exosome-mimetic hybrid vesicles with improved properties compared to the existing delivery nanoplatform that can be applied to cosmetics.