In general, skin active ingredients used in cosmetics are easily denatured by light, temperature and air, so their application to products requiring long-term preservation such as cosmetics is limited. Drug delivery technology that delivers effective ingredients to the skin is being developed in combination with nanotechnology. In this study, polymersomes are used as a material to increase stability and skin permeability. The most commonly known amphiphilic molecules are surfactants, phospholipids and block copolymers. These molecules have a double attraction in aqueous solutions, forming structures such as micelles, hydrogels and liposomes. Among them, polymersomes are self-assembled polymer-based bilayer vesicle made of a lipid-like biocompatible and biodegradable block copolymer amphiphilic media. Depending on the properties of the block copolymer, polymersomes of various types can be produced and provide improved structural stability compared to liposomes and niosomes. In addition, the hydrophilic compound is encapsulated in the aqueous core and the hydrophobic compound is loaded into the bilayer to facilitate selective release of the active substance. In this study, we focused on the application of biocompatible polymers to the cosmetic industry by using the self-assembling, tunable physicochemical properties of film-forming copolymers. The amphiphilic agent used to prepare polymersomes is a PEG-PCL-PEG-based triblock copolymer. First, a polymer and hydrogenated lecithin are mixed in an appropriate ratio. Polymersomes are prepared using a microfluidizer, a high-pressure micro-emulsification process. The particle size and zeta potential of the synthesized block polymer are measured. After a period of time, ester oil and hydrocarbon oil are applied to the proportion of polymersomes with little change in particle size. The emulsification ability of block polymers is compared according to the type of oil produced by the same high-pressure emulsification process. Oil-synthesized polymersomes are checked by particle size and surface charge. Also, the stable structure is confirmed through the analysis of the properties using an electron microscope. It can be seen that polymersomes are produced differently each content depending on the ratio of amphiphilic polymer to lecithin. As the content increases, the transparency of the polymersomes decrease and the particle size increase. It can be seen that the zeta potential is on a stable state at -30mV or more. When polymer and oil are applied during the manufacturing process, it can be seen that emulsification takes place. Through this, it can be confirmed that compatibility with oil is good. In this study, we found the optimal ratio to form a stable structure of polymersomes. An active substance that is unstable to the external environment was captured using polymersomes. The Synthesized polymersomes can increase skin permeability, so it is expected to secure technological competitiveness in the cosmetic industry.