Natural solution with skin microbiome friendly multifunctional activities
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Presented by: Amandine Fischer Desnos
Apocrine glands are larger sweat glands, restricted to the hirsute areas, predominantly in the axillae, perineal region, and scalp. They do not contribute to thermoregulation, but rather serve as scent glands. Gender, ethnicity, along with emotional, physiological and environmental factors influence the composition and quantity of one‘s sweat.
Axillae is an area where the bacterial density is the highest (2.4x106/cm²). Indeed, this is a hot and humid zone, rich in growth factors. Most skin bacteria are Gram positive: Micrococcaceae, mainly Staphylococcus species (104.4/cm²) (60% are S. epidermidis); aerobic Coryneforms, primarily Corynebacterium species (104.7-105.8/cm²), and anaerobic/microaerophilic Propionibacterium species.
The generation of odour on various sites of the human body, e.g. foot, mouth, or axilla, is mainly caused by microbial transformation of odourless natural skin secretions into volatile odorous molecules.
Gram-negative bacteria give nearly no contribution to the axillary malodour. Corynebacteria, generates intensive and pungent malodours, while high numbers of Staphylococci correlates with a “faint acid, nonapocrine” odour quality.
A consensus has emerged that short (C2–C5) and medium-chain (C6–C12) VFAs (such as 3M2H and HMHA), along with thioalcohols and 16-androstene steroids, are causal molecules of axillary malodour.
Zanthoxylum plants are known as ‘toothache trees’ due to their analgesic properties of their bark and fruit. Major ethnobotanical properties attributed to this plant specie are relief of dental problems, gastrointestinal disorders, effective for rheumatism, analgesic, and action against various skin diseases. Zanthoxylum’s berry is commonly eaten in Japan as a spice.
Zanthoxylum bungeanum fruit extract (ZBFE) is evaluated for its deodorising and skin microbiota friendly capacity.
Several tests are proceeded to evaluate ZBFE: astringency, Corynebacterium xerosis lipase inhibitory test, bacterial cytotoxicity is evaluated on Staphylococcus epidermis ATCC 12228 and Corynebacterium xerosis ATCC 373. A sniff test on axillary areas of human volunteers is carried on over an 8h journey against placebo.
ZBFE shows a +891% more astringent capacity than wine. It has no inhibitory properties on S.epidermidis and C.xerosis growth at normal usage level. At 3% it inhibits by -84,7% lipase from C.xerosis decreasing triglycerides hydrolysis into odoriferous compounds. Clinical expert self-evaluation of armpit odour after a single application of a roll-on formulation containing 3% FBFE shows a decrease by -57,1% of the odour after 8H compared to placebo.
There is a significant shift from the current reliance of deodorants on fragrances and broad-spectrum antimicrobial agents. A new generation of deodorant systems appears based on targeting specific bacteria, metabolic pathways or key enzymes.
Zanthoxylum bungeanum fruit extract (ZBFE) answers to this demand with a microbiota friendly action through inhibition of bacterial enzyme that generate odoriferous compounds.
Axillae is an area where the bacterial density is the highest (2.4x106/cm²). Indeed, this is a hot and humid zone, rich in growth factors. Most skin bacteria are Gram positive: Micrococcaceae, mainly Staphylococcus species (104.4/cm²) (60% are S. epidermidis); aerobic Coryneforms, primarily Corynebacterium species (104.7-105.8/cm²), and anaerobic/microaerophilic Propionibacterium species.
The generation of odour on various sites of the human body, e.g. foot, mouth, or axilla, is mainly caused by microbial transformation of odourless natural skin secretions into volatile odorous molecules.
Gram-negative bacteria give nearly no contribution to the axillary malodour. Corynebacteria, generates intensive and pungent malodours, while high numbers of Staphylococci correlates with a “faint acid, nonapocrine” odour quality.
A consensus has emerged that short (C2–C5) and medium-chain (C6–C12) VFAs (such as 3M2H and HMHA), along with thioalcohols and 16-androstene steroids, are causal molecules of axillary malodour.
Zanthoxylum plants are known as ‘toothache trees’ due to their analgesic properties of their bark and fruit. Major ethnobotanical properties attributed to this plant specie are relief of dental problems, gastrointestinal disorders, effective for rheumatism, analgesic, and action against various skin diseases. Zanthoxylum’s berry is commonly eaten in Japan as a spice.
Zanthoxylum bungeanum fruit extract (ZBFE) is evaluated for its deodorising and skin microbiota friendly capacity.
Several tests are proceeded to evaluate ZBFE: astringency, Corynebacterium xerosis lipase inhibitory test, bacterial cytotoxicity is evaluated on Staphylococcus epidermis ATCC 12228 and Corynebacterium xerosis ATCC 373. A sniff test on axillary areas of human volunteers is carried on over an 8h journey against placebo.
ZBFE shows a +891% more astringent capacity than wine. It has no inhibitory properties on S.epidermidis and C.xerosis growth at normal usage level. At 3% it inhibits by -84,7% lipase from C.xerosis decreasing triglycerides hydrolysis into odoriferous compounds. Clinical expert self-evaluation of armpit odour after a single application of a roll-on formulation containing 3% FBFE shows a decrease by -57,1% of the odour after 8H compared to placebo.
There is a significant shift from the current reliance of deodorants on fragrances and broad-spectrum antimicrobial agents. A new generation of deodorant systems appears based on targeting specific bacteria, metabolic pathways or key enzymes.
Zanthoxylum bungeanum fruit extract (ZBFE) answers to this demand with a microbiota friendly action through inhibition of bacterial enzyme that generate odoriferous compounds.