Our skin is subject to an increasing variety of stress in this present century from both external and internal factors that have the potential to cause damage including premature ageing. The external factors described include increasing exposure to sunlight, environmental pollution as well as controversial and putative contributions including electronic pollution and blue light. The interaction of the whole light components of sunlight (i.e. UV, visible light (including high energy blue light) and infrared light) as well their interaction with the other external stressors of skin are being elucidated but there are still areas where it is unclear. In addition, the differences in skin cell bioenergy and skin fatigue are linked to the mitochondrial theory of ageing particularly as mitochondria are the major source of cellular bioenergy and 90% of cellular oxidative stress. There is also the additional scenario of how the dynamic of external stressors interacts with the internal factors of stressed skin such as lifestyle and diet. We will consider what other interventions can be used to help prevent stressed out skin as part of the increasing personalised approach to skin protection.